Liquid crystal compound containing 4-tetrahydropyran structure and preparation method and application thereof,Chiral spiro indole-pyran pyridine alkaline compound and preparation and application thereof,Production method of burnt alcohol,Application of bi-methyl piperazinyl pyranone in preparation of fungal infection resisting drugs,Method for synthesizing naphthopyran-2-ketone compound

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In chemistry, pyran, or oxine, is a six-membered heterocyclic, non-aromatic ring, consisting of five carbon atoms and one oxygen atom and containing two double bonds. The molecular formula is C₅H₆O. There are two isomers of pyran that differ by the location of the double bonds. In 2H-pyran, the saturated carbon is at position 2, whereas, in 4H-pyran, the saturated carbon is at position 4.

Liquid crystal compound containing 4-tetrahydropyran structure and preparation method and application thereof

ActiveCN103319444AImprove stabilityLower threshold voltageLiquid crystal compositionsOrganic chemistryCrystallographyPhysical chemistry

The invention discloses a liquid crystal compound containing 4-tetrahydropyran and a preparation method and application thereof. The structural general formula of the compound is shown in a formula I (shown in a drawing). The compound has better thermal stability and moderate [delta]n, and a lower threshold voltage can be realized when the compound is applied to an optical device; the compound has very low rotational viscosity and high response speed and has very important practical significance in mixing a liquid crystal mixture with lower rotational viscosity. Thus, the compound is very suitable for mixing the liquid crystal mixture. The liquid crystal mixture containing liquid crystal monomers can be applied to multiple displays, particularly TN-TFT and STN (Super Twisted Nematic) displays, and can also be applied to an IPS display.

Owner:BEIJING CHENGZHI YONGHUA DISPLAY TECHNOLOGY CO LTD

Chiral spiro indole-pyran pyridine alkaline compound and preparation and application thereof

ActiveCN102321095AOrganic active ingredientsOrganic chemistryThioureaPharmaceutical Substances

The invention discloses a chiral spiro indole-pyran pyridine alkaline compound and a chiral synthesis method thereof, belonging to the field of biochemical technology. In the invention, a novel spiro indole-pyran pyridine alkaline compound is synthesized three-dimensionally and selectively by taking a 4-hydroxy coumarin compound or a 1-naphthol compound and a dicyan oxoindole olefin compound as reaction substrates and taking rosin-derived chiral thiourea as a catalyst. As proved by a biological activity experiment, the chiral spiro indole-pyran pyridine alkaline compound can selectively kill tumor cells, has strong actions on tumors of different types and has high selective broad spectrum anti-tumor activity. The chiral spiro indole-pyran pyridine alkaline compound can be taken as an anticancer active substance, and has a good application prospect in preparation of anticancer medicaments.

Owner:LANZHOU UNIV

Production method of burnt alcohol

PendingCN111011816AReduce dosageAppropriate flavor and fragranceFood scienceBiotechnologyFuran

A production method of burnt alcohol comprises the following steps: 1) pretreating malt: sequentially carrying out malt soaking, draining, protein resting, saccharifying and operating; (2) stir-fryingburnt malt: stir-frying the malt treated in step 1) in three steps of saccharifying, heating for baking burning and stir-frying burning, wherein the stir-frying burning is carried out at 270 DEG C orabove for 5 min or less; and 3) extracting burnt alcohol for 8-10 h by adopting ethanol with the alcohol concentration of 30-32%, at a soaking temperature 40 +/-2 DEG C and a solid-to-liquid ratio of50 g malt/100-200 ml ethanol. The alcohol with low concentration (30-32%) and medium-low temperature (40 +/-2 DEG C) is adopted to soak the stir-fried burnt malt in order to effectively extract pyrazines, furans, furanones, pyrone compounds and other burnt aroma components in the burnt malt, so that the burnt alcohol prepared by the production method of the burnt alcohol is rich in aroma components with various burnt fragrances, rich in burnt flavor, small in dosage and proper in flavor modulation.

Owner:湖南景然绿生态农业科技有限公司

Application of bi-methyl piperazinyl pyranone in preparation of fungal infection resisting drugs

InactiveCN103040830AGrowth inhibitionOrganic active ingredientsAntimycoticsCandida albicansBromine

The invention relates to application of bi-methyl piperazinyl pyranone in preparation of fungal infection resisting drugs and particularly discloses a substituted-piperazinyl-containing substituted pyranone compound 3-(2,5-trans-dimethyl-piperazin-1-ylmethyl)-6-(2-bromo-4,5-dimethoxy-phenyl)-2H-pyran-2-one or pharmaceutically acceptable salts thereof and a preparation method and medicinal application thereof. The in-vitro fungal growth inhibition activity of the compound is determined through a micro-dosage liquid-based dilution method; and shown by experimental results, the 80% growth inhibition concentration of the substituted pyranone compound to candida albicans is 125 micrograms / milliliter. Shown by pharmacodynamic results, the compound or pharmaceutically acceptable salts thereof can be expected to be applied to drugs for prevention and treatment of diseases caused by fungal infection.

Owner:DALI UNIV

Method for synthesizing naphthopyran-2-ketone compound

ActiveCN111205261AReduce dosageSimple and mild reaction conditionsOrganic chemistryMeth-Ptru catalyst

The invention belongs to the field of organic synthesis, and discloses a method for synthesizing a naphthopyran-2-ketone compound. The method comprises the following step: in the presence of benzoquinone, palladium acetate, 3-(4-methoxyphenyl) thiopropane-1-sodium sulfonate and a solvent, a phenolic compound and butyl acrylate react to obtain the naphthopyran-2-ketone compound carrying out a reaction. The phenolic compound is selected from one of the following structures as shown in the specification, wherein R1 is selected from hydrogen, halogen, alkoxy and ester group, R3 is selected from hydrogen, alkyl, alkoxy, trifluoromethyl, acyl and naphthyl, and R2 is selected from hydrogen or halogen. The reaction conditions are simple and mild, only one catalyst is needed, the use amount of thecatalyst is small and only needs 10 mol%, the reaction starts from olefin carboxylic ester, and therefore the reaction has higher economical efficiency. The reaction has good universality, is suitablefor substrates with different substituents, and has high yield.

Method for synthesizing naphthopyran-2-ketone compound

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Owner:HARBIN INSTITUTE OF TECHNOLOGY SHENZHEN (INSTITUTE OF SCIENCE AND TECHNOLOGY INNOVATION HARBIN INSTITUTE OF TECHNOLOGY SHENZHEN)