How to Candida albicans?

Durable antibacterial waterborne woodenware coating and preparation method thereof,Pure vegetable-fruit essence capable of diminishing inflammation, resisting bacteria and preventing infection, and preparation method thereof,Application of bi-methyl piperazinyl pyranone in preparation of fungal infection resisting drugs,Application of nerol in preparation of drug for preventing and treating oropharyngeal candidiasis

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Candida albicans is an opportunistic pathogenic yeast that is a common member of the human gut flora. It can also survive outside the human body. It is detected in the gastrointestinal tract and mouth in 40–60% of healthy adults. It is usually a commensal organism, but it can become pathogenic in immunocompromised individuals under a variety of conditions. It is one of the few species of the genus Candida that causes the human infection candidiasis, which results from an overgrowth of the fungus. Candidiasis is for example often observed in HIV-infected patients. C. albicans is the most common fungal species isolated from biofilms either formed on (permanent) implanted medical devices or on human tissue. C. albicans, C. tropicalis, C. parapsilosis, and C. glabrata are together responsible for 50–90% of all cases of candidiasis in humans. A mortality rate of 40% has been reported for patients with systemic candidiasis due to C. albicans. By one estimate, invasive candidiasis contracted in a hospital causes 2,800 to 11,200 deaths yearly in the US. Nevertheless, these numbers may not truly reflect the true extent of damage this organism causes, given new studies indicating that C. albicans can cross the blood brain barrier.

Durable antibacterial waterborne woodenware coating and preparation method thereof

ActiveCN108165146AImprove antibacterial propertiesOvercoming volatileAntifouling/underwater paintsPaints with biocidesAssociation typePolyamide

The invention relates to a durable antibacterial waterborne woodenware coating and a preparation method thereof. The coating comprises the following components: water soluble alkyd resin, a waterbornepolyurethane polyol dispersion body, an amino resin mixture, nano TiO2, nano ZnO, an association type thickener, a leveling agent, a defoamer, a basic wetting agent and deionized water, wherein the amino resin mixture is composed of methylated amino resin and ketone crosslinked polyamide polyamine epichlorohydrin with the weight ratio of 1:(0.2-0.6). The waterborne coating provided by the invention has durable antibacterial activity and mildew-proof performance, has a wide antibacterial spectrum, and has the killing effect on common pathogens such as staphylococcus aureus, streptococcus pneumonia, candida albicans, pseudomonas aeruginosa and aspergillus niger reaching 99.90% or more; through SGS ASTM F1980 tests, the woodenware coating still has the bacteriostasis rate of 99.30% or more 5years later, and has 5 years or more antibacterial effect.

Durable antibacterial waterborne woodenware coating and preparation method thereof

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Owner:肇庆易涂宝涂料有限公司

Pure vegetable-fruit essence capable of diminishing inflammation, resisting bacteria and preventing infection, and preparation method thereof

ActiveCN103316118AImprove permeabilityPromote absorptionAntibacterial agentsAntipyreticBiotechnologyHuman skin

The invention belongs to the medicine field, and specifically relates to a pure vegetable-fruit essence capable of diminishing inflammation, resisting bacteria and preventing infection, and a preparation method thereof the pure vegetable-fruit essence. The pure vegetable-fruit essence is prepared from the following raw materials by weight percentage: 10%-20% of cauliflower, 20%-30% of dandelion, 30%-40% of hawthorn or crataegus pinnatifida and 10%-20% of jasmine. The pure vegetable-fruit essence is suitable for developing a series of products for disinfection, sterilization and cleaning of environment, human body skin, furniture, clothing, equipment, tableware, vegetables and fruits, air and the like, and used for inhibiting bacteria and diminishing inflammation for the parts such as human body skin and mucosa. Detection indicates that the stock solution of antibacterial solution provided by the invention has an average sterilization rate of 100.00% for staphylococcus aureus, candida albicans and escherichia coli.

Owner:TONGHUA SWITANG PHARM TECH CO LTD

Application of bi-methyl piperazinyl pyranone in preparation of fungal infection resisting drugs

InactiveCN103040830AGrowth inhibitionOrganic active ingredientsAntimycoticsCandida albicansBromine

The invention relates to application of bi-methyl piperazinyl pyranone in preparation of fungal infection resisting drugs and particularly discloses a substituted-piperazinyl-containing substituted pyranone compound 3-(2,5-trans-dimethyl-piperazin-1-ylmethyl)-6-(2-bromo-4,5-dimethoxy-phenyl)-2H-pyran-2-one or pharmaceutically acceptable salts thereof and a preparation method and medicinal application thereof. The in-vitro fungal growth inhibition activity of the compound is determined through a micro-dosage liquid-based dilution method; and shown by experimental results, the 80% growth inhibition concentration of the substituted pyranone compound to candida albicans is 125 micrograms / milliliter. Shown by pharmacodynamic results, the compound or pharmaceutically acceptable salts thereof can be expected to be applied to drugs for prevention and treatment of diseases caused by fungal infection.

Owner:DALI UNIV

Application of nerol in preparation of drug for preventing and treating oropharyngeal candidiasis

InactiveCN111150720AAntimycoticsHydroxy compound active ingredientsFluorescenceEfficacy

The invention discloses an application of nerol in the preparation of a drug or pharmaceutical composition for preventing and treating oropharyngeal candidiasis, and belongs to the field of biologicalmedicine. The drug is a medicament prepared by using nerol as an active ingredient and adding a pharmaceutically acceptable auxiliary material. The real-time fluorescence quantification, ultravioletspectrum scanning and other technologies are used to find that nerol has relatively strong anti-Candida albicans effects at a relatively low dose of 1.54 [mu]L/mL. A mouse immunosuppression model is used to perform in vivo experiments, the prevention and treatment effect of nerol on oropharyngeal candidiasis is evaluated, fungal tests and histopathological examinations prove that nerol has relatively strong treatment effects on oropharyngeal candidiasis, and can be used for the preparation of the drug or pharmaceutical composition for preventing and treating oropharyngeal candidiasis.

Application of nerol in preparation of drug for preventing and treating oropharyngeal candidiasis