2 results about "Growth inhibition" patented technology

The invention discloses thioredoxin reductase inhibiter compounds, which have antitumor activity, particularly have growth inhibition activity for solid tumor, wherein the solid tumor is thyroid cancer, prostatic cancer, colon cancer, rectal cancer, melanoma, liver cancer, lung cancer, gastric cancer, carcinoma submaxilary gland, nasopharyngeal darcinoma or breast cancer.

The invention relates to application of bi-methyl piperazinyl pyranone in preparation of fungal infection resisting drugs and particularly discloses a substituted-piperazinyl-containing substituted pyranone compound 3-(2,5-trans-dimethyl-piperazin-1-ylmethyl)-6-(2-bromo-4,5-dimethoxy-phenyl)-2H-pyran-2-one or pharmaceutically acceptable salts thereof and a preparation method and medicinal application thereof. The in-vitro fungal growth inhibition activity of the compound is determined through a micro-dosage liquid-based dilution method; and shown by experimental results, the 80% growth inhibition concentration of the substituted pyranone compound to candida albicans is 125 micrograms / milliliter. Shown by pharmacodynamic results, the compound or pharmaceutically acceptable salts thereof can be expected to be applied to drugs for prevention and treatment of diseases caused by fungal infection.