70results about "Against vector-borne diseases" patented technology

We disclose the use of 25-OH D3 (calcifediol) to increase muscle strength, muscle function, or both. Vitamin D3 (cholecalciferol) may optionally be used together with 25-OH D3. Forms and dosages of a pharmaceutical composition, as well as processes for manufacturing medicaments, are also disclosed.

Provided herein are pharmaceutically acceptable sodium nitrite and pharmaceutical compositions thereof. Also provided herein are methods for determining the total non-volatile organic carbon in a sodium nitrite-containing sample. Further provided herein are methods for producing pharmaceutically acceptable sodium nitrite. Still further provided herein are methods of treatment comprising the administration of pharmaceutically acceptable sodium nitrite.

The present invention relates to a safe non-virulent Yersinia enterocolitica mutant strain for delivering heterologous proteins in target cells carrying mutations in at least one of the effector genes yopH, yopO, yopP, yopE, yopM, yopT genes and at least one additional mutation in the invasin genes chosen from yadA and/or inv. The present invention also relates to a safe non-virulent Yersinia enterocolitica mutant strain for delivering heterologous proteins in target cells according to claim 1 carrying mutations in all effector genes yopH, yopO, yopP, yopE, yopM, yopT genes and at least one additional mutation in the invasin genes chosen from yadA and/or inv. The present invention also relates to an expression vector for delivering a heterologous protein into a target cell using a Yersinia enterocolitica mutant strain according to any of the claims 1 to 4, which comprises in the 5' to 3' direction :(a) a promoter of a Yersinia virulon gene, (b) a first DNA sequence encoding a delivery signal from a Yersinia effector protein, operably linked to said promoter; and, (c) a second DNA sequence coding for said heterologous protein, fused in frame to the 3' end of said first DNA sequence. The present invention further relates to methods and compositions comprising (the use of) the afore-mentioned mutant strains and expression vectors.

The invention discloses vegetable insecticide of soluble matrine special for killing plant louses and a preparation method thereof, which aims at providing the vegetable insecticide which adopts Chinese herbal medicine as raw material, has high matrine content and low toxin but high efficiency, is harmless to human and livestock as well as special for killing plant louses and the preparation method thereof. The invention comprises 11-13 portions of Chinese herbal medicine extract containing the matrine, 10-20 portions of emulsifier, 4-8 portions of penetrating agent, 0.1 portions of antioxidant and 57-64 portions of deionized water; the Chinese herbal medicine extract containing the matrine is the extract of the mixture by weight of 15-25 portions of sophora flavescens ait, 10-17 portions of chinaberry tree, 3-4 portions of argy wormwood leaf, 6-8 portions of celastrus angulatus maxim, 4-8 portions of derris, 2-4 portions of gardenia, 7-9 portions of herba artemisiae, 10-14 portions of gelsemium elegans, 5-7 portions of orange seed and 7-10 portions of Chinese wingnut leaf. The insecticide of the invention comprises the matrine with super high content about 1.3 percent and is special for killing the plant louses through scientific preparation of a plurality of Chinese herbal medicines and has powerful penetrating performance, high efficiency and insignificant toxin and is in favor of absorption by plants.

The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises both the polysaccharides levan and inulin.

The invention provides a heat clearing and detoxifying herbal tea. The herbal tea comprises the following components, by weight, 5-10 parts of gypsum, 5-10 parts of Rhizoma Anemarrhenae, 5-10 parts of Wrinkled Gianthyssop, 5-10 parts of honeysuckle flower, 5-10 parts of Lithospermum erythrorhizon, 5-10 parts of licorice, 5-10 parts of wild chrysanthemum flower, 5-10 parts of Cogongrass rhizome, 5-10 parts of radix scutellariae and 5-10 parts of Artemisia carvifolia. In the heat clearing and detoxifying herbal tea, the honeysuckle flower and the wild chrysanthemum flower have heat clearing, detoxifying, and wind-heat cooling and scattering functions, the matching of the gypsum and the Rhizoma Anemarrhenae has flesh heat clearing, excess fire purging, dry stomach moistening, stomach fire clearing, lung dryness removing and polydipsia quenching functions, the Lithospermum erythrorhizon has heat clearing, blood cooling, spot transforming, detoxifying, blood circulation invigorating and rash expelling functions, the Cogongrass rhizome has a heat clearing function without the damage to the kidney and the yin, the Artemisia carvifolia has heat clearing and malaria preventing functions, and the Wrinkled Gianthyssop has aromatizing, turbidity transforming, appetizing and vomiting preventing functions, so the heat clearing and detoxifying herbal tea can clear away heat, detoxify, transform dampness and expel pathogenic factors.

The invention discloses an establishment method for a type 2 diabetes mellitus animal model. The establishment method comprises the following steps: (1) preparing a lipopolysaccharide solution with aconcentration of 100ug/ml by virtue of normal saline; (2) selecting male rats which are 4-6 weeks old, feeding by virtue of a common feed, and simultaneously injecting the lipopolysaccharide solution;(3) weighing the male rats after 28 days; (4) after the weighing, fasting for 8 hours, separating serum, and measuring blood glucose and insulin; (5) evaluating the resistance of the insulin and glucose stimulated insulin secretion capacity; (6) respectively intraperitoneally injecting an STZ solution into the male rats in the 30th day and the 32th day; and (7) determining that the establishmentof the type 2 diabetes mellitus animal model is finished when the random blood sugar is more than 16.8mmol/L. According to the establishment method, lipopolysaccharide in Escherichia coli 0111:B4 subspecies is selected and is matched with the feeding of the common feed and the STZ injection so as to successfully establish the type 2 diabetes mellitus animal mode; according to the establishment method, the operation is easy, the model establishment cost is low, the model establishment rate is high, and the model establishment period is short.

An insect repellent composition containing citronella oil, D-limonene, 2 or more synergists, and 3 or more essential oils as the active ingredients. The preferred essential oils are geranium oil, rosemary oil and peppermint oil, but other essential oils may be used. In the preferred embodiment the synergists are aldehyde C-14 and aldehyde C-18. As desired, vanillin may be used as a stabilizer, and fragrances, fragrance enhancers and surfactants may be utilized.

The invention discloses a plant culicifuge. The plant culicifuge comprises, by weight, 10-12 parts of lavender, 13-15 parts of licorice root, 8-10 parts of peppermint oil, 3-5 parts of citronella oil, 8-10 parts of menthol, 20-30 parts of Artemisia argyi, 5-7 parts of wintergreen oil and 30-50 parts of eucalyptus citriodora oil. The plant culicifuge prepared from pure natural raw materials has substantial efficacy of preventing mosquito biting, sterilizing and relieving itches, reduces influences of mosquito biting on people's daily life, has fresh smell, makes people using the plant culicifuge be refreshed, and is suitable for promoted use.

The invention discloses an efficient environmentally friendly ecological insecticide for a garden. The insecticide is prepared from, by weight, 40-50 parts of plant dry powder, 3-6 parts of inorganic bases, 14-18 parts of binder, 15-19 parts of insecticide synergist, 7-9 parts of surfactant, 2-4 parts of realgar, 4-6 parts of penetrant, 8-10 parts of stabilizer, 8-14 parts of propylene glycol and 120-160 parts of water. The efficient environmentally friendly ecological insecticide for the garden is harmless to plants, the insecticidal effect is good, the insecticide is unlikely to dry and volatilize, the efficacy time is long, and the control efficiency of garden plant pests such as red spider, aphid, whitefly, scale insect, pseudaulacaspis pentagona, Aromia bungii, Spodoptera litura, tortrix, loopworm, Arge pagana and the like is good; a number of plant insecticidal components which are nontoxic and harmless to environment are used in the raw materials; meanwhile, according to the preparation method provided, the production cost is low, the process is concise, and the preparation method has high practical value and good application prospects.

The invention belongs to the field of medicine and personal care, and particularly relates to propolis-aloe bacteriostatic gel and a preparation method thereof. The propolis-aloe bacteriostatic gel isprepared from the following raw materials in percentage by mass: 8-12% of golden cypress, 8-10% of fructus cnidii, 6-11% of stemona, 9-12% of fructus kochiae, 7-9% of divaricate saposhnikovia roots,4-8% of seaweeds, 3-6% of aloes, 0.5-0.8% of propolis, 1-1.4% of chlorhexidine acetate, 0.8-1.2% of carbomer 940, 0.08-0.11% of methylparaben, 0.09-0.12% of triethanolamine, 0.9-2.1% of ethanol and 36-40% of purified water. The propolis-aloe bacteriostatic gel is propolis-aloe gel prepared through the compound compatibility of the propolis and the aloes, through the synergistic effect of the propolis and the aloes, the effects of inhibiting the growth of bacteria, promoting wound healing, diminishing inflammation, realizing sterilization, realizing moistening and nourishing, replenishing water, removing acne, removing eczema and realizing spot-fading can be effectively achieved, and especially, the bacteriostatic effect on escherichia coli, staphylococcus aureus, hemolytic streptococcus and the like is achieved.

The invention discloses a portable tick trapping device. The portable tick trapping device comprises a top cover (2), an inducing device and a capturing device and is characterized in that the capturing device comprises a base (4) and a side plate (3), a barrel-shaped body with an opening in the upper portion is formed by the side plate (3) and the base (4), tick adhering glue (11) is arranged on the inner surface of the base (4) and/or the inner surface of the side plate (3), cracks (12) are formed in the side plate (3), and the top cover (2) and the side plate (3) are hinged through a support (13); the inducing device comprises an inducing core (10) and a carbon-dioxide generator (6), a constant temperature heating piece (5) is arranged on the base, the inducing core is arranged on the base (4) in the mode that an opening of the inducing core faces downward, multiple vent holes (8) are formed in the surface of the inducing core (10), and an animal hair filling cavity (9) is formed in the opening of the inducing core (10). Compared with the prior art, the portable tick trapping device has the advantages that materials are cheap and wide in source, and the trapping device is convenient to carry, easy to operate and high in tick capturing efficiency.

The invention discloses a formula and production method of a pesticide for preventing and controlling icerya purchasi. The pesticide is prepared by adding tobacco powder and artemisia annua powder to a certain amount of boiled water in a heating container in proportion to be sufficiently stirred and decocted, naturally cooling and filtering the decocted liquid, packaging and sealing clear liquid obtained after filtering, and adding water to dilute the stock solution for spraying when the stock solution is used. The formula and preparation method of the pesticide are unique, the pesticide is a biological pesticide, the prevention and control effect on icerya purchasi damage can reach 93%, and the pest killing effect is remarkable. The pesticide is free of toxin and harm to humans, animals and trees and is safe to use. The production raw materials of the pesticide are wide in source, tobacco powder is screen residue waste in tobacco production, artemisia annua is field weed, waste is used, and cost is low.

The invention discloses PCR (polymerase chain reaction) detection primers for three bacteria and the application of the PCR detection primers. The three bacteria are alicyclobacillus aacillus, escherichia coli and salmonella. The upstream detection primer of the alicyclobacillus aacillus has the SEQIDNO.1, and the downstream detection primer has the SEQIDNO. 2. The upstream detection primer of the escherichia coli has the SEQIDNO.3, and the downstream detection primer has the SEQIDNO.4. The upstream detection primer of the salmonella has the SEQIDNO.5, and the downstream detection primer has the SEQIDNO.6. The multiple PCR detection method provided by the invention has the biggest advantages that the one PCR tube can be used for detecting three bacteria, the PCR detection efficiency is improved, and the errors caused by misoperation during detection are reduced.

The invention belongs to the field of high-molecular compounds obtained through a carbon-carbon unsaturated bond reaction, and particularly relates to a soluble silver ion-containing polymerizable monomer, a preparation method thereof, a silver-containing polymer and an antibacterial coating. The soluble silver ion-containing polymerizable monomer can be dissolved in water or an organic solvent, and has a structure of A(AgLn)x, wherein L is a ligand capable of being complexed with silver, n is the number of ligands, A is an acid radical ion, and x is the number of acid radical negative charges; wherein at least one of A and L contains a carbon-carbon double bond. According to the soluble polymerizable monomer containing the silver ions, the polymerizable monomer containing the silver ionsis prepared in a complexing mode, and the silver ions are combined to carbon-carbon unsaturated bonds in a covalent bond or ionic bond mode. The polymerizable monomer can be dissolved in water or an organic solvent, and a silver ion-containing aqueous solution coating, a silver ion-containing organic solvent coating or a silver ion-containing emulsion coating can be conveniently obtained in a homopolymerization or copolymerization mode.

The invention discloses a driven medical intelligent defecation assisting mechanism system. The system comprises an intelligent toilet module, a base station processing module and a central regulatingmodule; the intelligent toilet module comprises a sanitation box body, a handrail frame, a backrest and a cushion spring; the base station processing module comprises a processing chamber, a rubbishaccommodation device, a sleeve bag device, a socket, a water injecting head, a camera and an electronic water valve; the central regulating module comprises a central centralized control unit, a monitoring unit, a signal transmission unit, an instruction transmission unit, a route planing unit and an image processing unit. According to the system, a movable intelligent toilet module and an integrated system which is used for performing management and controlling on the intelligent toilet module are designed aiming at the situation of concentrated hospital patients to greatly improve the convenience and the working intensity of medical workers.

The invention discloses a synthesis method of EPS-RB nanometer particles for photodynamic bacterium resistance. Lactobacillus plantarum exopolysaccharides EPS, rose-bengal RB, 1-(3-dimethylaminopropyl)-3-ethylenediamine hydrochloride EDC-HCl and N-hydroxysuccinimide NHS are used as raw materials; reaction is performed in dimethyl sulfoxide DMSO to obtain compounds EPS-RB; the compounds EPS-RB aresubjected to self assembly to form spherical nanometer particles in a water solution; a good photodynamic bacterium resistance effect is achieved. The compound can realize the self aggregation in thesolution to form nanometer particles; the nanometer particles generates singlet oxygen higher than free RB under the light illumination condition, so that the photodynamic bacterium resistance on escherichia coli and staphylococcus aureus is superior to that of the free RB. The concentration required by EPS-RB nanometer particles for completely killing escherichia coli and staphylococcus aureus isrespectively 8mu M and 500nM; the concentration required by the free RB is respectively 16 mu M and 1000nM.

The invention relates to a real-time fluorescent PCR detection kit for bumblebee microsporidia and a detection method thereof, which are specially used for detecting bumblebee microsporidia. The kit comprises: (1) a positive standard; (2) negative control; (3) PCR reaction solution; (4) ExTaq enzyme; (5) sterile water. The invention has the following advantages: (1) good stability and specificity:detection of bumblebee microsporidia has high specificity, has no cross reaction with other microsporidia and bumblebee pathogens, and has good repeatability; (2) high sensitivity: the sensitivity can reach 20 copies/[mu] L; (3) easy and fast operation: the whole reaction can be completed within 2 hours. The kit can be used for detecting Nosema bombycis and differentiating and diagnosing the Nosema bombycis from other Nosema bombycis, and has important significance for early prevention and timely treatment of the disease. The kit can be used for detecting Nosema bombycis and differentiating and diagnosing the Nosema bombycis from other Nosema bombycis.

The invention discloses a WFR (Weil Felix Reaction) test card used for detecting typhus rapidly. The WFR test card aims to solve the disadvantage that the classical WFR test stilled adopted for clinical defection of the typhus is fussy to operate and time-consuming. The WFR test card comprises a pad, wherein the pad is provided with a sample pad with water absorbency, a glass fiber strip, a chromatography film and an absorbing pad with water absorbency in a fixing manner sequentially from left to right; the glass fiber strip is uniformly coated with colorful latex particles with marks; the right end of the sample pad is jointed to the glass fiber strip; the right end of the glass fiber strip is jointed to the left end of the chromatography film; the left end of the absorbing pad is jointed to the right end of the chromatography film; the chromatography film is provided with a test line and a control line; the control line is positioned at the right side of the test line; and the test line is formed by fixing one of proteus OX19, proteus OX2 and proteus OXK on the chromatography film. The WFR test card has the advantages of being capable of detecting the typhus rapidly and having simple and convenient detection operations as well as low production cost.

This invention provides one rapid test bar for 0139 cholera vibrio antigen, which covers 0139 cholera vibrio antibody and IgG on NC film and combines glue gold label 0139 vibrio antigen single clone antibody and applies film analysis double antibody clamper and tests label 0139 cholera vibrio antigen.

Creatinine, creatinine precursors or the pharmaceutically acceptable salts thereof are activated to function as an antibacterial agent which has broad spectrum activity and is beneficially used in a variety of applications, such as antimicrobial wound dressings, compositions for topical delivery of the antibacterial agent and for preventing and/or inhibiting the occurrence or spread of bacterial infection, as well as the growth of odor-causing bacteria, to name a few.

The present invention relates to antimalarial agents. In particular, the present invention relates to the use of bisbenzimidazoles of Formula I for the prevention and/or treatment of malaria,

wherein n is an integer selected from 0 to 10, and

• R¹ and R² are each independently selected from hydrogen, halogen, hydroxyl, alkyl, alkoxy, amino, alkylamino, alkylcarbonylamino, alkylcarbonyloxy, formyl, alkylcarbonyl, alkyloxycarbonyl, halocarbonyl, haloalkyl, haloalkoxy, carbamoyl, cyano, nitro, sulfo, or a carboxyl group.

The invention is suitable for the technical field of LED lamps, and provides a LED lamp for livestock breeding. The lamp comprises: an installation module, a shell, and an LED lamp body located in the shell; an induction mechanism, which is located in the shell, wherein the induction mechanism comprises an induction assembly and a killing assembly used in cooperation with the induction assembly, the induction assembly is used for sucking mosquitoes and insects into the shell, and the killing assembly is used for killing the mosquitoes and insects sucked by the induction assembly; a deinsectization mechanism, which is connected with the shell, wherein the deinsectization mechanism comprises a deinsectization assembly and a cleaning assembly used in cooperation with the deinsectization assembly, and the deinsectization mechanism is used for achieving the deinsectization and treatment work on the mosquitoes and insects. a driving mechanism, which is used for driving the induction assembly and the cleaning assembly to work. The LED lamp for livestock breeding is innovative in structure, and through the arrangement of an induction mechanism and a deinsectization mechanism, the deinsectization and treatment function of the LED lamp for livestock breeding is conveniently achieved.