149results about "Material analysis" patented technology

The present invention relates to molecules, particularly polypeptides, more particularly immunoglobulins (e.g., antibodies), comprising a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region, which variant Fc region binds FcγRIIIA and/or FcγRIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection. The molecules of the invention are particularly useful for the treatment or prevention of a disease or disorder where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.

The present invention provides a monoclonal anti-idiotype antibody 11D10 that elicits an immune response against a specific epitope of a high molecular weight mucin of human milk fat globule (HMFG) and a hybridoma that produces 11D10. The hybridoma that produces 11D10 was selected by specific procedures. 11D10 induces an immunological response to HMFG in nice, rabbits, monkeys and patients with advanced HMFG-associated tumors. This invention provides compositions derived from polynucleotide sequences encoding the variable light and/or variable heavy regions of monoclonal anti-idiotype antibody 11D10, as well as polypeptides encoded thereby. The invention also provides compositions which can be used in the detection or treatment of HMFG-associated tumors.

The invention discloses an anti-drunk driving and safe-health driving method which comprises the following steps: combining the heart rate change and body temperature change of a driver in a vehicle, alcohol concentration detection in the vehicle and a third party remote video monitor and control so as to judge whether the driver is drunk and guard against the drunk driving of the driver in a plurality of ways; and giving a health safety warning and rational suggestion to the driver according to the abnormal change of the heart rate caused by high-speed driving or long-time fatigue driving ordrunk driving of the driver. By utilizing the anti-drunk driving and safety-health driving method, a more rigorous and initiative anti-drunk driving method is formed so that the driver cannot subjectively and deliberately escape the drunk detection; the limitation and misjudgment of a way for judging whether the driver is drunk by singly detecting the alcohol concentration in the vehicle is solved, and the accident caused by drunk driving is reduced; and meanwhile, the anti-drunk driving and safety-health driving method is good for the cardiovascular health of the driver, and can be used for reducing the high-speed driving syndrome of the driver.

The invention discloses a full-automatic urine analyzer and a test paper plate used for the same. A selecting mechanism of the full-automatic urine analyzer mainly comprises a hollow test paper box and a lifting device, wherein the lifting device is connected with the test paper box and can drive the test paper box to move up and down integrally; a boost groove is arranged at the bottom side of the test paper box; a test paper outlet is arranged at the back side of the test paper box; a detection block is arranged in a matrix shape on the front side of a substrate; and the test paper blocks are frontally placed inside the test paper box When in service, boost teeth arranged on a conveying mechanism smoothly pass through the boost groove and push the bottommost test paper plate stored in the test paper box out from the test paper outlet to a conveyer belt. The invention has the advantages of simple structure, low cost, quick selection, reliable detection result and the like.

The use of porous monolithic matrix for matrix-assisted laser desorption/ionization time of flight mass spectrometry analysis on a sample suspected of containing an analyte is herein described. The porous polymer monoliths provide a matrix suitable for use in detecting and analyzing low molecular weight and small molecules. The matrices described herein also facilitate the creation of arrays of monolithic matrices for high-throughput detection and screening using MALDI-TOF mass spectrometry and exhibit a long shelf-life.

The invention discloses a sensor for monitoring metal abrasive particles in oil liquid on line. The sensor is a mutual inductance sensor and comprises an exciting coil and an inducting coil, wherein an oil path through which the oil liquid can pass is arranged in the center of a framework made of a magnetic inert material; the exciting coil and the inducting coil are coaxially wound on the framework; the inducing coil is positioned between the exciting coil and the framework; the axial length of the inducting coil is 1/4-1/2 of that of the exciting coil; and the axial center points of the inducting coil and the exciting coil are superposed. The sensor realizes zero compensation and adjustment by adopting a parallel measurement structure and is simple in structure, high in sensitivity, high in linearity and high in interference resistance. The sensor applied to on-line monitoring for the metal abrasive particles in the oil liquid is convenient to operate, high in instantaneity, high in measurement precision and accurate and reliable in monitored result and can be widely applied to military and civil fields and used for monitoring the pollution degree and the abrasion to the oil liquid of lubricating systems of mechanical equipment such as various air planes, naval vessels and automobiles and monitoring and diagnosing faults of the lubricating systems of the mechanical equipment to avoid safety accidents.

The invention relates to a method of treatment of resistance to platelet inhibitors, i.e. a method to overcome resistance of treatment with platelet inhibitors, said method comprising administering a therapeutically effective amount of dipyridamole in combination with a platelet inhibitor and, optionally, in combination with a third antithrombotic component such as direct thrombin inhibitors, factor Xa inhibitors, combined thrombin/factor Xa inhibitors, heparin, low molecular weight heparin, argatroban, bivalrudin, hirulog or polyglycans to a patient in need thereof. The invention further relates to the use of dipyridamole for the manufacture of a pharmaceutical composition for treatment of resistance to platelet inhibitors. The invention also relates to a method to diagnose resistance to treatment with platelet inhibitors, said method comprising measurement of the density of binding of Annexin V on platelets.

The invention discloses a portable grain situation detection device, comprising a shell which is provided with a gas collecting inlet and a gas collecting outlet; the shell is internally provided with a detection circuit which comprises a single chip microprocessor, a temperature and humidity sensor, a carbon dioxide sensor and a micro-typed pneumatic pump; the temperature and humidity sensor and the carbon dioxide sensor are connected with the single chip microprocessor which is connected with the micro-typed pneumatic pump by a power driving unit. The portable grain situation detection device can be held by hand for use, is convenient for carrying, has fast detection speed, simple operation and exact result, and can meet the requirement of grain situation detection in national grain depots. The portable grain situation detection device of the invention is suitable for the early detection of grain storage fungi and pest damages, and ventilation effect evaluation in a grain depot, and ensures the safety of the management personnel of grain depots.

The invention relates to a mercury-containing fumes emission continuous monitoring system and a monitoring method thereof. The monitoring system comprises a sampling device, a reactor, a gas and water separating device, and a mercury concentration measuring device which are sequentially connected through a pipeline; the reactor is connected with a first container containing a divalent mercury adsorption solution through a first peristaltic pump, and is also connected with a second container containing a divalent mercury reduction solution through a second peristaltic pump; and the sampling device, the first peristaltic pump, the second peristaltic pump and the mercury measuring device are separately electrically connected with a control circuit. The monitoring method comprises: firstly, the divalent mercury adsorption solution is pumped into the reactor to adsorb the divalent mercury in the fumes, and the mercury concentration measuring device is used to measure the concentration of zero valent mercury in the fumes; secondly, the divalent mercury reduction solution is pumped into the reactor to reduce the divalent mercury to be zero valent mercury, and the concentration obtained by the mercury measuring device at the same time is the concentration of the mercury in the fumes. The monitoring system of the invention is simple in structure, can prevent environment pollution, is highly reliable, achieves on-line automatic continuous monitoring, and improves operation efficiency and measurement accuracy.

The invention discloses a reaction incubation device, an immunity analyzer and a reaction incubation method. The reaction incubation device comprises a reaction unit (10) and a transfer unit (20), wherein the reaction unit (10) is use for bearing and incubating a reaction container; the transfer unit (20) is used for removing the reaction container in and out of the reaction unit (10); the reaction unit (10) comprises a rotating device (11); the rotating device (11) is provided with an incubation position; the incubation position moves a predetermined angle theta at an interval of fixed time T along with the rotating device (11); and the transfer unit (20) removes the reaction container out of the incubation position according to variable incubation time t1. Flexible and variable incubation time can be simply and efficiently achieved, and the problems that control is complicated, the reliability is low and high-speed automation is not easy to achieve in the prior art to achieve the variable incubation time are effectively solved.

This invention relates to indoor air quality tester in monitoring field, which is aimed at VOC content as reference, which comprises the following key points: the tester comprises shell, LCD display screen, single machine and matched functional parts, wherein, the shell front side is located with display screen, keys, aim sucking window and its back is located with aim sucking window and battery case. The said single machine and the matched functional parts are connected to the air sensor, humidity sensor, thermal sensor, clock signals, key connection and with its output end connected to LCD display screen and pre-warning device.

The present invention relates to a microfluidic device used for cell motility screening and chemotaxis testing which comprises microfluidic channels and chambers. Cells which can secret a chemoattractant or chemorepellent are selectively planted in the microfluidic device and a stable chemoattractant or chemorepellent gradient can be established in the channels.

The invention provides an ELISA (enzyme linked immunosorbent assay) kit for detecting PRRS antibody and application thereof, belonging to the field of biotechnology. The kit comprises an ELISA slat with recombinant GST-GP5 (glutathione transferase-glycoproteins) protein as coating antigen, a PBS (polydiethylene glycol sebacate) solution, a blood serum diluted solution, a rabbit anti-pig enzyme-labelled bi-antibody, a colour-developing substrate, a terminating liquor, PRRS positive blood serum, PRRS negative blood serum and the like. The kit provided by the invention is used for detecting PRRS antibody; after the indexes like specificity, sensitivity, repeatability and the like of a detection method are inspected, the method is used for detecting serum samples; and the detection coincidence rate with the ELISA kit in the prior art is 90%. The kit provided by the invention has the advantages that the operations are convenient, the repeatability is good, and the kit is suitable for being popularized and applied; a reliable measure for fast detecting PRRSV (pig progenitive and respiratory syndrome virus) antibody is supplied clinically.

The invention provides an anti-aflatoxin general type monoclonal antibody hybridoma cell line and application thereof, belonging to the field of food safety immunodetection. The cell line 1G6 provided by the invention is collected in the China General Microbiological Culture Collection Center (CGMCC) with a collection number of CGMCC No.7210. After an aflatoxin complete antigen is uniformly mixed with equivalent Quick Antibody immunologic adjuvant TM, an obtained mixture is injected to immunize BALB/c mice through leg muscle. B1-KLH (fumonisin B1-Keyhole Limpet Hemocyanin) is adopted for the first time of immunization, M1-KLH (fumonisin M1-Keyhole Limpet Hemocyanin) is adopted for the second time of immunization, and an M1 complete antigen (without containing adjuvant) is adopted for the last time of impaction immunization. Splenocytes of immunized mice are fused with myeloma cells through a PEG (polyethylene glycol) method, and the hybridoma cell line 1G6 is obtained through indirect ELISA (Enzyme-Linked Immuno Sorbent Assay) and indirect competence ELISA screening and three times of subcloning. A monoclonal antibody secreted from the cell line has better affinity and detection sensitivity for aflatoxins B1, B2, G1, G2 and M1, and can be used for immunodetection of the total quantity of the aflatoxins in the food safety.

The invention discloses an odor identification method based on gas sensors and deep learning, which is characterized in that a response curve cluster of odor to be detected is obtained through a gas sensor array, original data is directly used as an input sample of an odor identification deep neural network, data preprocessing and data amplification are performed on the input sample, time sequenceresponse data hierarchical features are automatically extracted by adoption of deep learning, global feature extraction and long-range dynamic feature extraction are performed at the same time, and an odor label is output through a classifier, so that high-sensitivity and specific odor identification is realized. The odor identification method of the invention has high sensitivity and high reliability, and can be widely applied to the fields of industrial production, medical treatment, environment, safety and the like.

A method for comparing odors comprises: sampling odor sources and detecting primary odorants, then for each odor source, storing each of the sampled odor sources in respective primary vectors of odor descriptors that describe the primary odorants. For each source a source vector is then constructed by summing the primary vectors of the respectively detected primary odorants. Comparison between the odors is achieved by determining an angle between the source vectors, which may then be output. The method may be used in electronic noses and like equipment.

The invention discloses an experiment apparatus having a certain pressure adsorption state by quantitative addition of moisture in coal body. The experiment apparatus comprises two high pressure steel cylinders, the high pressure steel cylinders are connected with gas filling pipelines through a balance tank, the quantity of gas filling pipeline is three, and the gas filling pipelines are respectively connected with a first coal sample pot, a reference pot and a second coal sample pot, the first coal sample pot and the second coal sample pot respectively pass through a high pressure water-injection pipeline and is connected with a high pressure ball valve, a non return valve, a non return valve, a metering pump and a liquid injection pump in order, the first coal sample pot and the second coal sample pot respectively pass through a dispersion pipeline to connected with a fixed space, the pressure sensors are arranged on the upper part of the dispersion pipeline and in the fixed space, and a dispersion valve is arranged on the pipeline. The experiment apparatus can accurately control the liquid feeding amount, realizes the high pressure liquid feeding, besides water injection, realizes whole-process computer control, and has the advantages of high control precision and high experiment result accuracy, can simulate complete and real well coal body environment, and can fully satisfy the requirement of a liquid feeding experiment for coal body under the certain pressure adsorption state.

The present invention belongs to the field of toxic matter detecting technology. The detection method of quickly detecting veterinary medicinal residue in food and agriculture and sideling products includes the following steps: applying coupled antigen of several kinds of veterinary medicines as micro array on solid carrier and coating; mixing deluent diluted biotinylated antibody and measured sample, competitive immunogical reaction with the coated veterinary medicinal antigen, and washing with detergent; adding avidin marked colloidal gold for amplification and colorizing, and obtaining grey result with scanning instrument. The competitive immunogical method of the present invention has the features of high sensitivity, high specificity and simple operation.

The invention provides an immunoassay method and a kit for detecting concentration of cyclosporine A. According to the immunoassay method, cyclosporine C is used as a competing molecule to quantitatively detect the concentration of cyclosporine A in a sample. The invention also provides an immunoassay kit for detecting concentration of cyclosporine A. By utilizing the immunoassay method provided by the invention to detect cyclosporine A, an anti-cyclosporine-A antibody with relatively low affinity can be used to obviously improve the analytical sensitivity, so that the detection result is high in accuracy and good in exactness.

The invention discloses a vomitoxin quantitative determination kit and a use method thereof. The vomitoxin quantitative determination kit comprises a magnetic separation reagent 1, a resist 2, an enzyme-labelled antigen agent 3, a cleaning solution 4, a calibrator and a quality control 5, a substrate solution 6 and a stop solution 7, wherein the magnetic separation reagent is a magnetic particle suspension combined with an FITC(fluorescein isothiocyanate)-DON antibody; the resist is an FITC-labelled anti-DON antibody solution, and the enzyme-labelled antigen agent is a DON solution coupled with a biological enzyme. The vomitoxin quantitative determination kit have the remarkable advantages of simple, quick, sensitive and accurate operation, and suitability for detecting vomitoxin samples in food or feed on a large scale daily.

Systems and methods collect and screen a biological material to facilitate its selection and use for therapeutic and/or research purposes. The systems and methods take into account both objective and semi-objective attributes manifest in a biological material, such as genetic, phenotypic, clinical, and genealogic attributes. The diverse array of the objective and semi-objective attributes enhances the level of confidence that the biological material can be best matched with a particular research or therapeutic purpose.

The invention belongs to the field of bioenvironment material degradation property research, which comprises: separating from the environment and getting the degraded bacterium of every degradation materials, sorting and attesting and forming the mixing bacterium group, designing the device to measure the discharge of the carbon dioxide in the degradation process. Said invention measuring the degradation ability according to the principle of the mixing bacterium group can measure the carbon dioxide transformed from organic carbon in the high polymer, and because using the mixing bacterium group, the result has a good repeatability and can be used widely.