3 results about "Binding peptide" patented technology

Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging., etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof.

The invention provides a gold nanostar for identifying and degrading PD-L1 on the surfaces of prostate cancer cells as well as a preparation method and application of the gold nanostar, and relates to the technical field of biological medicines. According to the invention, PD-L1 binding peptide, autophagy induction peptide and the gold nanostar are utilized for the first time, and a nano-particle capable of identifying and efficiently degrading PD-L1 on the surfaces of prostate cancer cells are successfully constructed. According to the method, the PD-L1 binding peptide and the autophagy induction peptide are grafted to the surface of the gold nanostar, and PD-L1 is recognized and degraded through a nanodevice, so immune escape of prostate cells is inhibited, anti-tumor immunity is enhanced, the progress of prostate cancer is inhibited, and the purpose of treating prostate cancer is achieved.