Sample measurement device, sample measurement system and sample measurement method

a technology of sample measurement and sample, applied in the direction of diaphragms, cells, immobilised enzymes, etc., can solve the problems of measuring accuracy suffer, and achieve the effect of reducing measurement errors

Active Publication Date: 2010-11-11
PHC HLDG CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0055]The present invention provides a sample measurement device, a sample measurement system, and a sample measurement method with which measurement error can be reduced.

Problems solved by technology

However, because an enzyme reaction is highly temperature dependent, temperature changes during measurement, etc., can cause measurement accuracy to suffer.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

embodiment 1

1. Embodiment 1

[0096]A biosensor measurement system (sample measurement system) 100 pertaining to Embodiment 1 of the present invention will now be described. Blood is used here as the specimen (sample). The specific component to be measured is the glucose concentration.

[0097]1.1 Biosensor Measurement System 100

[0098]FIG. 1 is a simplified diagram of the constitution of the biosensor measurement system 100 in Embodiment 1. Those components that are the same as in the biosensor measuring system 700 in FIG. 12 are numbered the same in FIG. 1.

[0099]The biosensor measurement system 100 of Embodiment 1 comprises a biosensor 30 and a measuring device (sample measurement device) 110. The biosensor 30 is held directly in the hand of the user, and is mounted in the measuring device 110 to perform measurement. The configuration of the biosensor 30 is the same as that shown in FIG. 13, and will not be described again here.

[0100]1.2 Measuring Device 110

1.2.1 Configuration of Measuring Device 11...

embodiment 2

2. Embodiment 2

[0170]The biosensor measurement system (sample measurement system) 100 pertaining to Embodiment 2 of the present invention will now be described.

[0171]Those components that are the same as in Embodiment 1 will be numbered the same. Also, since the constitution of the biosensor measurement system and the measuring device is the same as that in Embodiment 1, it will not be described in detail again here.

[0172]2.1 Operation of Measuring Device 110

[0173]The measuring device 110 pertaining to Embodiment 2 (FIG. 1) differs from that in Embodiment 1 in that the applied voltage value for measuring (the set value for measuring) is changed on the basis of the detection time T from the mounting of the biosensor 30 to the measuring device 110 until the biosensor 30 detects that a specimen has been deposited.

[0174]FIG. 8 is a graph of the measurement profile in Embodiment 2, and the current response curve thus obtained. In this embodiment, in the third step the voltage V2 is lower...

modification examples

4. Modification Examples

[0203](1)

[0204]In Embodiments 1 and 2 above, the tables Tb1 and Tb2 are referred to in changing the set value (measurement time or applied voltage), but the set value may instead be calculated from a specific mathematical formula according to the detection time T or the measurement temperature.

[0205]Also, a calculation formula may be used that makes use of a coefficient or a parameter other than the detection time T or the measurement temperature.

(2)

[0206]In Embodiments 1 and 2 above, a case was discussed in which either measurement time or applied voltage is changed in the method for measuring the glucose concentration in blood deposited on the biosensor 30, but the present invention is not limited to this, and the same effect can be anticipated when both measurement time and applied voltage are changed.

(3)

[0207]In Embodiments 1 and 2 above, it was decided that no extension of the measurement time was necessary when the detection time T exceeded 20 seconds, ...

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PUM

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Abstract

A sample measurement device (110), in which a biosensor (30) having an electrode is mounted, voltage is applied to the electrode, and the concentration of a specific component in a sample deposited on the biosensor (30) is measured, comprises a voltage source (19) configured to apply voltage to the electrode, a time measurement component (22), and a controller (18) configured to control the voltage to be applied and measure the concentration of the specific component. The time measurement component (22) measures a detection time, which is the length of time between the mounting of the biosensor (30) and the deposition of a sample on the biosensor (30). The controller (18) changes a set value for measuring the concentration of a specific component according to the detection time. Consequently, measurement accuracy can be improved regardless of the temperature of the biosensor (30).

Description

TECHNICAL FIELD[0001]The present invention relates to a sample measurement device, a sample measurement system, and a sample measurement method, with which a biosensor is used to quantify a specific component in a sample.BACKGROUND ART[0002]A biosensor is a sensor in which an ability to recognize the molecules of a biological material, such as microbes, enzymes, or antibodies, is utilized, and a biological material is used as a molecular labeling element. Specifically, a fixed biological material makes use of a reaction that occurs when a targeted specific component is recognized, the consumption of oxygen by the respiration of microbes, an enzyme reaction, light emission, and so forth. In particular, biosensors that make use of enzyme reactions have seen considerable practical application, and are used in the medical and food preparation fields.[0003]An example of a biosensor measuring system that makes use of an enzyme reaction will now be described through reference to FIGS. 12 a...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01R27/08G01K1/00
CPCG01N27/327G01N27/3274
Inventor NAKAMURA, TOSHIFUMISHINNO, TEPPEI
Owner PHC HLDG CORP
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