The invention discloses an application of porphyrin in tin in preparation of medicines for treating thalassemia, which uses porphyrin in tin for intraperitoneal injection of beta thalassemia mice, and finds that porphyrin in tin can enable invalid red systems of thalassemia mice to return to normal, so that alpha/beta globin chain imbalance of red blood cells is effectively relieved, and the curative effect of thalassemia is improved. The red blood cell life, the total red blood cell number and the hemoglobin level are improved; meanwhile, the iron content and splenomegaly of serum and liver are reduced. After porphyrin in tin is used for treatment, invalid hematopoiesis, anemia and iron overload of thalassemia mice are effectively relieved, no obvious toxic or side effect exists, treatment is convenient to implement, and the curative effect can be kept only by maintaining low dosage after high dosage.