22 results about "Chemical synthesis" patented technology

The invention discloses a novel andrographolide derivative and analogue as well as a preparation method of the novel andrographolide derivative and analogue and an application to the treatment, the prevention and the relief on human viruses and neoplastic diseases. The invention also relates to a medicine composition of the compound and an application as antivirus and anticancer disease medicine. Through chemical synthesis and preparation, semi-synthesis multi-series andrographolide analogues can be obtained.

The invention provides a culture method for pleurotus eryngii, and relates to a technology of applying the stems of shiitake mushroom to pleurotus eryngii culture. Compared with the prior art, the method has the advantages that 1, the shiitake mushroom stems soaking solution is a pure natural nutritional solution containing various types of bioactive substances; the culture materials and the shiitake mushroom stems soaking solution are stacked and fermented to prompt the growth of hypha of pleurotus eryngii, namely, hypha grows well and is high in deformity resistance rate; 2, the shiitake mushroom stems soaking solution can rejuvenate the hypha after picking the first flush, which prompts the formation of primordium of pleurotus eryngii as well as the growth of the entity; the second flush and the second flush are large in size, high in quality and high in biological efficiency; 3, the problem that the quality of pleurotus eryngii is lowered down due to chemical synthesized fertilizer used for a long term is solved, thus the quality of pleurotus eryngii is improved, and meanwhile the output is increased; the total biological efficiency is raised by 40% by being compared with that of the control group; 4, fuel used for sterilizing at high temperature is saved, so that the energy is saved, and the shortage that the emission of carbon dioxide generated in traditional production of edible mushrooms is increased can be removed.

The invention belongs to medicine chemical synthesis field, especially relates to method for synthesizing 16- dehydrogenating pregnene acyloin acetic ester and medicine intermediate of the same kind with steroid saponin. The pseudosapogenin cracked from steroid saponin reacts with oxygen under existence of light and sensitizer, or with catalyst pyridine and acetic anhydride, and product is acidolysized directly to get final product. The invention is characterized by elimination of chromic anhydride pollution used as oxidant, irrigid temperature control, simple post treatment process, and increased productivity.

The invention discloses a preparation method of 2-amino-5-chloropyridine, and belongs to the field of organic chemical synthesis. The method comprises the following steps of using 2-amino-pyridine as a raw material and N-fluoro-N-chlorobenzene sulfonamide as a chlorinating agent, in an organic solvent, using imidazole ionic liquid as a catalyst, and carrying out a reaction, wherein a reaction temperature is 0 to 40 DEG C, and a reaction time is 0.2h to 24h. The method provided by the invention is simple and convenient in preparation process, mild in reaction condition, low in cost and high in product yield.

The invention provides a zero-calorie fruit-flavored vitamin drink, which is prepared by mixing nutrition enhancers, stevioside, fructose, natural spices, natural pigments, and sour agents with water; the zero-calorie fruit-flavored vitamin drink of the present invention Stevioside is used as the main sweetener to replace sucrose and other chemically synthesized sweeteners in existing functional beverages, reducing the sugar content and calorific value of beverages; the natural flavors contained in it not only improve the taste but also affect the Good for human health.

The invention belongs to the field of chemical synthesis, and particularly relates to a preparation method of 2-methylaziridine. The 2-methylaziridine is synthesized from isopropanolamine, sulfuric acid and liquid caustic soda as raw materials, the synthesis condition is mild, and mass industrial production is facilitated. Besides, the synthesis materials are simple, sulfate esterification and liquid caustic soda hydrolysis are adopted, caustic soda flakes are used for purification in the distillation and purification process, few byproducts are produced, and the method is green and environmentally friendly; initial distillation under normal pressure and fine distillation under low pressure are adopted, and the obtained 2-methylaziridine has the purity of 99% or above.

The invention belongs to the field of medicinal chemical synthesis and in particular relates to a method for preparing 4-amino-2,6-dihydroxypyrimidine by virtue of a dry frying process. The method forpreparing 4-amino-2,6-dihydroxypyrimidine by virtue of the dry frying process comprises the following concrete steps: by taking sodium methoxide dry powder, urea and methyl cyanoacetate as raw materials, reacting under certain conditions, heating at a certain temperature, steaming out generated methanol, and finally generating 4-amino-2,6-dihydroxypyrimidine. According to the invention, yield of4-aminopyrimidine obtained through cyclization reaction can reach 80-85%, and product purity is more than 99%. Compared with a liquid-phase cyclization method, the method provided by the invention hasthe advantages that reaction yield can be improved by more than 15%, reaction period is reduced to be 2-3 hours from the original more than 8 hours, and no water methanol is produced, so that pollution of organic wastewater is greatly reduced, preparation cost and energy consumption of 4-amino-2,6-dihydroxypyrimidine are greatly reduced, and the method provided by the invention is hopeful to being applied to industrial production.

The invention discloses a method for preparing and synthesizing magnesium carbonate from magnesium chloride and carbon dioxide, and belongs to the technical field of chemical synthesis. In the method, uses the magnesium chloride which is a byproduct after extracting potassium from salt lake and carbon dioxide discharged in industrial process are used as reactants to prepare magnesium carbonate; and simultaneously, hydrochloric acid generated in the reaction process is moved out of a water phase using an extraction agent. The solid magnesium carbonate generated in the reaction is subjected to the steps of separating, washing, drying and the like to obtain solid magnesium carbonate trihydrate with high purity. By adopting the method, the waste magnesium chloride in the form of water soluble salt is converted to the solid magnesium chloride with slight solubility, which is conductive to large-scale storage and prevents salt lake pollution caused by back-infiltration of magnesium salt, a lot of CO2 gas is sealed and stored at the same time when the magnesium salt is immobilized, which is conductive to the reduction of CO2 discharge amount, and the magnesium carbonate which is immobilized for sealing and storage in large scale can be taken as resource reservation and reused when the technology is mature.

The invention discloses a technical solution of collecting a sequence of a mycoplasma pneumoniae gene from Genbank, establishing gene data of mycoplasma pneumoniae, and analyzing the gene data throughcomputer software to obtain a segment which has detection activity of mycoplasma pneumoniae adhesion protein P1 (GenBank: AF286371.1) and adhesion protein P30 (GenBank: EF614306.1), and connecting 252nd-355th amino acids (P1A), the 898th-953rd amino acids (P1B), 1274th-1362nd amino acids (P1C), 1589th-1627th amino acids (P1D) of the P1 gene, and a P30 fragment of174th-274th amino acid of the mycoplasma pneumoniae adhesion proteinP30 in series through connecting peptides GSGSGS, wherein the sequence of connections in series is sequentially a P1A fragment-a first connecting peptide-a P1B fragment-a second connecting peptide-P1C-a third connecting peptide-P1C-a fourth connecting peptide-P1D-a fifth connecting peptide-a P30 fragment from a C terminal to an N terminal, and the corresponding nucleic acid sequence is obtained by a chemical synthesis method.

A label that permits rebridging of disulfide linkages in antibodies or proteins. The label has a general formula given by

wherein R₁ is methyl, ethyl or propyl and R₂ is a metal chelator, a fluorophore or a click-chemistry synthon.

The invention discloses a preparation method of 3-fluoro-4-cyanophenol, which belongs to the field of organic chemical synthesis. 2,4-difluorobenzonitrile is adopted to prepare 2-fluoro-4-alkoxy benzonitrile by virtue of substitution reaction, and then 3-fluoro-4-cyanophenol can be obtained by virtue of hydrolytic reaction. By adopting the preparation method, the production cost can be reduced, the product purity and yield can be improved, and the preparation method has the advantages of ease in obtaining raw materials, mild reaction conditions, simplicity in operation, and suitability for industrialized mass production.

The invention discloses a highly-conductive carbon material and a low-temperature preparation method thereof. The low-temperature preparation method is characterized in that a precursor rich in terminal alkynyl groups is reacted in a gas atmosphere or a vacuum environment to obtain black solid powder which is the highly-conductive carbon material; the precursor rich in terminal alkynyl groups contains at least three terminal alkynyl groups; and the precursor rich in terminal alkynyl groups has a conjugate structure. The carbon material is obtained through low-temperature chemical synthesis under very mild conditions by using the precursor rich in terminal alkynyl groups through using the high activity characteristic of the alkynyl groups, the preparation efficiency of the low-temperature preparation method is greatly more than that of existing carbon material preparation technologies, and the carbon material obtained through the method has the advantages of good conductivity, good stability and excellent processing performances. The method has the advantages of simple process, low cost, wide application range, facilitation of industrial large-scale production, and facilitation of further promotion of the carbon material to many application fields needing mild conditions.

The invention relates to the field of organic chemical synthesis, in particular to an esdoxaban tosylate intermediate and a preparation method thereof, and the esdoxaban tosylate intermediate has the advantages of simple and convenient preparation process, mild reaction conditions, low cost and easily available raw materials. The synthesis method comprises the following synthesis steps: by taking a compound N-methyl-4-piperidone as a raw material, carrying out substitution reaction on the compound N-methyl-4-piperidone and bromine to generate a compound as shown in a formula (II); the compound shown in the formula (II) and sodium sulfide are subjected to a sulfo-reaction, and a compound shown in a formula (III) is obtained; carrying out cyclization reaction on the compound as shown in the formula (III) and glyoxylic acid to obtain a compound as shown in a formula (IV); carrying out esterification reaction on the compound shown in the formula (IV) and alcohol to obtain a compound shown in a formula (V), and reacting to obtain a compound shown in a formula (VI); or directly reacting the compound shown in the formula (IV) under the action of alcohol and acid to obtain the compound shown in the formula (VI); and carrying out alkaline hydrolysis and acid neutralization on the compound shown in the formula (VI) to obtain a compound shown in a formula (VII). The reaction formula is shown in the specification.

The invention discloses a process for synthesizing hydrogenated terphenyl heat-conducting oil, and belongs to the technical field of chemical synthesis. The process comprises the processes of biphenyl synthesis, distillation and hydrogenation. In the biphenyl synthesis process, pure benzene and a catalyst are subjected to a high-temperature reaction in a reactor, the catalyst comprises a carrier and an active component, and the mass of the active component accounts for 10-35% of the mass of the carrier; the carrier is modified activated carbon or a molecular sieve, and the active component is a composite oxide of CuMgAl, CuFeAl, CuFeZn and CaMgZn. In the terphenyl synthesis stage, the supported catalyst with a composite metal oxide as the active component is adopted as the catalyst, so that the selectivity of terphenyl is improved, the generation of by-products such as quaterphenyl and pentaphenyl is reduced, and finally the purity of the hydrogenated terphenyl heat-conducting oil is improved.

The invention discloses an application of a providencia bacterial strain in preparation of a divalent manganese oxidant. The providencia bacterial strain can also be applied to degradation of atrazine in polluted water body. The invention further provides a kit and a method for economically and simply preparing manganese oxide, thereby overcoming defects of hostile reaction conditions, complicated operations, high cost and low efficiency in existing chemical synthesis technologies of manganese oxide.

The invention relates to a preparation method of a dexzopiclone photodegradable impurity, and belongs to the technical field of chemical synthesis. The invention relates to a preparation method of 6-(5-chloropyridin-2-yl)-6, 7-dihydro-5H-pyrrolo [3, 4-b] pyrazin-5-one (compound I), which is prepared by reacting a compound II or a compound III with diisobutylaluminum hydride under certain conditions. The invention provides a synthetic method of the 6-(5-chloropyridin-2-yl)-6, 7-dihydro-5H-pyrrolo [3, 4-b] pyrazin-5-one (compound I), which is reasonable in process, mild in condition and simple and convenient to operate, and the method is simple to operate and has a certain commercial value.

The invention discloses a rotenone microcapsule suspending agent and a preparation method thereof. The rotenone microcapsule suspending agent comprises the following components by weight percentage: 0.03-1.8 percent of rotenone and 0.1-0.5 percent of emulsifying agent, wherein the rotenone microcapsule suspending agent takes the rotenone as the active ingredient and takes star anise oil as the emulsifying agent. According to the invention, the star anise oil directly extracted from a plant replaces other chemosynthetic aromatic organic solvents to be used as the emulsifying agent to prepare the rotenone microcapsule suspending agent, so as to enable the rotenone microcapsule suspending agent to enter the ranks of environment-friendly formulations. As the star anise oil extracted from the star anise is directly utilized, the economic benefits of essential oil plant planters are improved, the production cost of pesticide is reduced, the control effect of the rotenone microcapsule suspending agent is improved, a pure natural synergistic pesticide formulation is further created, and meanwhile, all components and corresponding contents of the rotenone microcapsule suspending agent enable the rotenone microcapsule suspending agent to have favorable control effect.