40 results about "Perylene derivatives" patented technology

The invention discloses benzoperylene imide derivatives, and a preparation method and application thereof. The structural formula of the benzoperylene imide derivatives is disclosed in the specification. The benzoperylene imide derivatives are prepared by carrying out multiple reactions on the initial raw material 3,4,9,10-perylene tetracarboxylic acid anhydride. The benzoperylene imide derivatives have strong blue light absorptivity, the molar absorption coefficient at the maximum absorption wavelength reaches 50000 mol<-1>cm<-1> above, the benzoperylene imide derivatives have no absorption in other visible light regions within the range of 500-800nm; and the spectrum properties of the derivatives can be utilized to prepare the blue light absorbing material which is applicable to the field of daily high-energy short-wave radiation prevention, such as mobile phone screen anti-blue-light coatings, eyeglass anti-blue-light coatings, paper anti-blue-light painting and the like.

The invention discloses an oxygen-fluorine liposome microbubble therapeutic agent which consists of microbubbles, and oxygen and at least one perfluocarbon existing in the microbubbles, wherein the gas nucleus takes oxygen as a principle component and takes perfluocarbon as an auxiliary component, and the microbubble mainly consists of phospholipid and polyethylene glycol derivative. According to the oxygen-fluorine liposome microbubble therapeutic agent, oxygen can be controlled to be released in a human body through veins delivery and targeted hypoxia tissue under ultrasound wave irradiation, the hypoxia disease is treated, and the therapeutic agent serves as a contrast agent used for ultrasonic enhanced imaging. Therefore, the microbubble is a developing agent and an oxygenating therapeutic agent.

Provided herein are asphalt compositions comprising asphalt, a carboxylated copolymer, a polyalkyleneimine, and a photoinitiator. The carboxylated copolymer present in the asphalt compositions can be a latex composition derived from a carboxylated styrene-butadiene copolymer. The carboxylated copolymer includes from 0.5% to 25% by weight carboxylic acid monomers. The carboxylated styrene-butadiene polymer and the asphalt can be present in a weight ratio of from 1:99 to 1:10. The polyalkyleneimine present in the asphalt compositions can be in an amount of greater than 0% to up to 10% by weight of the asphalt composition. The photoinitiator can include benzophenone and/or a derivative thereof. Tack coats meeting ASTM-D-977 standard comprising the asphalt compositions disclosed herein are also provided. The tack coat can have a tack-free time of 10 minutes or less. Methods of producing the asphalt compositions and tack coats are also disclosed.

An objective of the present invention is to provide carbapenem derivatives which have strong antibiotic activity also against MRSA, PRSP, Influenzavirus, and β-lactamase producing bacteria and are stable to DHP-1. The carbapenem derivatives according to the present invention are compounds represented by formulae (I) and (II) or pharmaceutically acceptable salts thereof:

wherein R¹ represents H or methyl, R² and R³ each independently represent H; halogen; substituted or unsubstituted alkyl; cycloalkyl; substituted or unsubstituted alkylcarbonyl; carbamoyl; substituted or unsubstituted aryl; substituted or unsubstituted alkylthio; morpholinyl; alkylsulfonyl; or formyl, n is 0 (zero) to 4, and Hy represents a substituted or unsubstituted monocyclic or bicyclic heterocyclic group.

The invention provides a preparation method and application of a chitosan-g-poly(epsilon-caprolactone) derivative drug-loaded nano-micelle. According to the invention, chitosan and a poly(epsilon-caprolactone) derivative provided are used for the drug-loaded nano-micelle; the preparation method is simple in process and convenient in operation; a drug with poor water solubility can be encapsulatedand conveyed, the systemic toxicity of the drug is reduced, the biocompatibility of a carrier is improved, and the curative effect of the drug is improved; and the chitosan-g-poly(epsilon-caprolactone) derivative drug-loaded nano-micelle disclosed by the invention has hydrophobic groups and hydrophilic groups which are easily degraded in a living body, can be used as a novel drug-loaded nano-micelle, has a wide substantive application scope, and has very important practical value for treating tumors.

The present invention provides a technology for, in copper electrolytic plating containing silver ions as an alloy component, obtaining a copper electrolytic plating film in which co-deposition of sulfur can be significantly suppressed and which is excellent in physical properties such as strength and hardness even after a high-temperature heat treatment at about 200° C. or higher. The present invention is a copper electrolytic plating bath comprising copper ions, an acid, chloride ions, and a complexing agent, wherein the copper electrolytic plating bath further comprises silver ions as an alloy component, and wherein methionine or a derivative thereof is contained as the complexing agent.

The invention provides a cephalotaxine derivative. The cephalotaxine derivative has a structure as shown in a formula I or a pharmaceutically acceptable salt or stereoisomer of the cephalotaxine derivative. The cephalotaxine derivative provided by the invention can effectively inhibit the growth of various tumor cells, especially can inhibit Ba/F3-BCR/ABL-T315I mutant cells, is a novel protein synthesis inhibitor capable of overcoming BCR-AblT315I drug-resistant mutation, can be used for preparing anti-tumor drugs, and has a wide market application prospect.

The invention discloses an oleanolic acid oxime ester derivative and a preparation method and application thereof. According to the invention, oleanolic acid is taken as a raw material, a series of derivatives are synthesized through oxime esterification, lead compounds with good biological activity are obtained, and the synthesized OA derivative shows a glycosidase inhibition effect far higher than that of OA and has important biological activity. The oleanolic acid (OA) oxime ester derivative has a remarkable inhibition effect on the activity of alpha-glucosidase and alpha-amylase, the inhibition effect of the compound 3a on the alpha-glucosidase is the strongest, and IC50 is 0.35 mu M and is about 1900 times stronger than that of acarbose; the compound 3f has the strongest inhibition effect on alpha-amylase, and IC50 is 3.80 mu M and is about 26 times higher than acarbose. Researches show that the oleanolic acid oxime ester derivatives have reversible inhibition mechanisms and mixed inhibition mechanisms on alpha-glucosidase and alpha-amylase respectively.

The invention discloses a light-emitting compound, a light-emitting layer material, an organic electroluminescent device and electronic equipment, and relates to the technical field of organic light-emitting materials, and the structural general formula of the light-emitting compound is as shown in the structural formula (1). The light-emitting compound is a benzidine derivative, ring formation modification is introduced to a benzidine structure with steric hindrance so that vibration of a donor structure can be restrained, then a rigid receptor is combined, a rigid D-A framework is formed, and the narrow emission spectrum characteristic can be easily achieved; besides, the benzidine structure is correspondingly modified, so that the energy level band gap and the light emitting color of the compound can be further regulated and controlled, and the commercial color standard is realized. Meanwhile, due to the large steric hindrance effect of the donor unit and the acceptor unit, accumulation of luminescent molecules can be avoided to a great extent, exciton quenching caused by the accumulation effect is inhibited, the luminous efficiency of the compound in an organic electroluminescent device is improved, and the photoelectric property requirement of a commercial organic electroluminescent device is met.

The invention relates to the field of medical chemistry, and aims at providing a substituted furan chalcone derivative and a preparation method thereof. The substituted furan chalcone derivative has the structure shown in a formula (I): wherein B ring is selected from phenyl, furyl or thienyl; R1, R2, and R3 are respectively and independently selected from hydrogen atom, halogen, hydroxyl, cyan, nitro, C1-C7 alkyl chain, C1-C7 alkoxy, and dimethylamino or diethylamino. The product is a kind of natural furan chalcone analogues with a new framework, the product has potential medicament activity, and the preparation of the compound can provide support for activity researches of furan chalcone medicaments. The preparation method has simple steps and low loss late, and provides a brand new route for synthesis of the furan chalcone derivative from nonaromatic raw materials. The method has an important meaning for industrial production.

The invention discloses a method for synthesizing a 1, 3-disubstituted planar chiral metallocene compound, and belongs to the field of organic synthesis. According to the method disclosed by the invention, simple N, N-alkyl amino methyl ferrocene/ruthenium and aryl iodide or aryl bromide are taken as initial raw materials and are stirred to react in an organic solvent at 80 DEG C under the action of a palladium catalyst, chiral amino acid, a norbornene derivative and alkali, so that the 1, 3-disubstituted planar chiral metallocene compound can be obtained. The method has the advantages of cheap and easily available raw materials, mild reaction conditions, good substrate universality, high yield and simple preparation process.

The invention provides an organic compound and an organic light-emitting device using the organic compound, and particularly relates to a soluble organic compound with excellent color purity, high brightness and high luminous efficiency and an OLED device using the organic compound. The structure of the organic compound is as shown in formula 1, in the structural formula, Ar1 and Ar2 are respectively and independently selected from substituted or unsubstituted C1-C30 alkyl, substituted or unsubstituted C1-C30 aryl, substituted or unsubstituted C10-C30 fused ring group, substituted or unsubstituted C6-C90 heteroaryl, substituted or unsubstituted C13-C30 amine derivatives (wherein, one must be a substituted or unsubstituted C6-C90 heteroaryl group, a heterocyclic group, or a substituted or unsubstituted C13-C30 amine derivative containing two or more nitrogen atoms); R1 and R2 are a substituted or unsubstituted C1-C30 alkyl group, a substituted or unsubstituted C1-C30 aryl group, a substituted or unsubstituted C10-C30 fused ring group, or a substituted or unsubstituted C3-C30 heteroaryl group, and R1 and R2 may be linked to form a ring.

The invention provides application of trilobatin in preparation of a medicine for preventing and/or treating non-alcoholic fatty liver disease. The trilobatin is researched and found for the first time to be capable of improving blood glucose metabolism disorder, abnormal blood lipid metabolism, liver function impairment, liver inflammatory response, liver injury, liver fatty degeneration and lipid deposition caused by the non-alcoholic fatty liver disease, and the trilobatin and the derivative thereof have a good treatment effect on the non-alcoholic fatty liver disease. The invention provides a novel and efficient natural medicine source for treating the non-alcoholic fatty liver disease.

The invention provides a green method for converting a thiazolidine derivative into a carbonyl compound, and belongs to the field of green organic synthetic chemistry. According to the method, a co-catalysis system is formed by H2O2-CeBr3 under neutral, open and room-temperature conditions, hypobromous acid is generated in situ by H2O2-CeBr3 to serve as a direct oxidizing agent, and the tetrahydrothiazole derivative is oxidized into the corresponding carbonyl compound within a short time. The used reagents H2O2 and CeBr3 and the solvent acetonitrile are cheap and easy to obtain, the reaction is mild and efficient, the product yield is high, the tolerance of functional groups is good, the operation is simple and convenient, the method is environment-friendly, the application of the tetrahydrothiazole protecting groups in organic synthesis is effectively expanded, and the method has a good application prospect.

The invention discloses an azulene isoindigo derivative as well as a preparation method and application thereof. The azulene isoindigo derivative has a large-pi conjugated system, a reversible oxidation-reduction property, an adjustable dissolution-promoting alkyl chain and a reversible proton response property; in addition, the azulene isoindigo derivative can also be polymerized to form a novel organic functional material; and besides, the azulene isoindigo derivative has a plurality of chemical active sites, different sites can be modified and connected, the preparation method is simple, raw materials are cheap and easy to obtain, and the purity of a target compound is high.

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of N-(cyano (2-cyano substituted phenyl) methyl) substituted tertiary amine. The reaction general formula is shown in the description. According to the invention, N, N-disubstituted amino-malononitrile and substituted 2-(trimethylsilyl) phenyl trifluoromethane sulfonate are subjected to a substitution reaction under the action of a catalyst to synthesize the N-(cyano (2-cyano substituted phenyl) methyl) substituted tertiary amine compound. The method has the advantages of easily available initial raw materials, simple operation, mild reaction conditions and cheap catalyst, can reduce the input amount of funds and labor force, and provides a rapid and efficient preparation method for the N-(cyano (2-cyano substituted phenyl) methyl) substituted tertiary amine derivative.

The embodiment of the invention provides a perovskite solar cell, and the perovskite absorption layer comprises a compound with a chemical general formula of ABX3, and comprises an interface modification layer which comprises at least one of crown ether or a crown ether derivative; an interface modification layer comprising crown ether or a derivative thereof is introduced into a perovskite solarcell. A complex film layer with crown ether groups and second-order ions of metal B is formed at a grain boundary and an interface of a perovskite absorption layer of the perovskite solar cell. Sincethe crown ether has a hydrophobic external skeleton, a hydrophilic inner cavity which can be bonded with metal ions is formed. After a complex film layer is formed at a grain boundary or an interfaceof a perovskite absorption layer, the effect of isolating H2O, O2 and O3 is achieved. The influence of three-dimensional perovskite crystal decomposition or crystal phase state conversion on the current density of the perovskite solar cell can be prevented, defects are filled at the crystal boundary and the interface, the interface defects are reduced, the series resistance is reduced, and the parallel resistance is increased, so that the filling factor of the cell is increased, and the service life of the perovskite solar cell is prolonged.

The invention discloses a ferulic acid derivative as well as a preparation method and application thereof, and belongs to the technical field of medicine research. The target ferulic acid derivative is prepared by acylating chlorination of ferulic acid and further esterification condensation with a serine derivative and lipoic acid condensation product. Wherein the used lipoic acid can eliminate free radicals for accelerating aging and pathopoiesis; the lipoic acid has the characteristics of fat solubility and water solubility, so that the lipoic acid can pass through the whole body, can reach any cell part, and provides comprehensive efficacy for a human body; meanwhile, serine is adopted as a linking part of ferulic acid and lipoic acid, the chiral structure of the serine is utilized, so that the compound has better targeting property, and the serine is a safe substance after in-vivo degradation and has better safety in vivo; the prepared ferulic acid derivative has the characteristics of good nephritis curative effect, high activity, low toxicity to other organs, good druggability and the like.

The invention provides a spiro[cyclopropane-1, 2'-indene]-1', 3'-diketone derivative and a synthesis method thereof, and belongs to the technical field of organic synthesis of medical intermediates. The method comprises the following steps: adding a proper solvent and a proper alkali into a container filled with a substituted 2-ethylidene-1H-indene-1, 3 (2H)-diketone compound and a substituted sulfur ylide compound, stirring at a proper reaction temperature, filtering after the reaction is finished, adding water or a saturated salt aqueous solution into the filtrate, extracting with an organic solvent, carrying out drying, carrying out reduced pressure distillation concentration to remove the solvent, and carrying out column chromatography separation on the crude product to obtain the target product spiro[cyclopropane-1, 2'-indene]-1', 3'-diketone derivative.The method has the advantages of being efficient in reaction, convenient and rapid, wide in substrate adaptability, high in diastereoselectivity, high in yield and the like and has good industrial application prospects.

The invention relates to a method for preparing a quinoxaline-2-ketone derivative through controllable catalysis. The method comprises the following steps: adding a Selectfluor reagent into an organic solvent, carrying out ultrasonic dissolution, respectively adding a quinoxaline-2-ketone compound, an alcohol and an additive into the organic solvent, carrying out a stirring reaction at room temperature under the irradiation of a light source, tracking by TLC until the raw material quinoxaline-2-ketone compound is completely reacted, then ending the reaction, and carrying out post-treatment and column chromatography separation and purification to obtain the 3-alkoxy quinoxaline-2-ketone derivative or the 3-hydroxyalkyl quinoxaline-2-ketone derivative. Clean visible light is used as reaction energy, the preparation process is simple and efficient, operation is convenient, conditions are mild, environment friendliness is achieved, the substrate application range is wide, and the method is suitable for large-scale industrial production.

The present invention relates to a method and a unit for preparing a solid material for storing ozone, said method comprising contacting cyclodextrins and/or derivatives of cyclodextrins in solid form with a gas comprising ozone, by means of which a solid material for storing ozone is obtained. The present invention also relates to the material thus prepared and to the uses thereof.