The invention provides a
chalcone compound as well as a preparation method and application thereof, and belongs to the technical field of chemical medicines. The
chalcone compound is a compound as shown in a formula I, or a
crystal form thereof, or a salt thereof, or a stereoisomer thereof, or a solvate thereof, or a
hydrate thereof, or a
prodrug thereof. Wherein R < 1 > to R < 8 > are independently selected from
hydrogen, C1-C6
alkyl groups, hydroxyl groups and C1-C6 alkoxy groups respectively. The
chalcone compound with remarkable anti-inflammatory activity is obtained by extracting, separating and purifying
abelmoschus esculentus seeds. The compound and the derivative thereof can be used as synthesis primers of other compounds and raw materials for new
drug development and pharmacological activity research, can be used for preparing anti-inflammatory drugs, can be used as natural products for developing new traditional Chinese medicines, and has a wide medical application prospect.