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Method of establishing crania-cerebral explosion impact injury animal model,Sample post office,Fluorescein derivative and synthetic method thereof

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3 results about "Medical research" patented technology

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Biomedical research (or experimental medicine) encompasses a wide array of research, extending from "basic research" (also called bench science or bench research), – involving fundamental scientific principles that may apply to a preclinical understanding – to clinical research, which involves studies of people who may be subjects in clinical trials. Within this spectrum is applied research, or translational research, conducted to expand knowledge in the field of medicine.

Method of establishing crania-cerebral explosion impact injury animal model

InactiveCN103099686AAvoid injuryAvoid burnsSurgical veterinaryShock waveEngineering

The invention relates to a method of establishing a crania-cerebral explosion impact injury animal model in the medical research field. The method of establishing the crania-cerebral explosion impact injury animal model is characterized in that a big rat (7) is fixed on a shield plate (2) with a window hole (3), a back side of a head of the big rat (7) is aligned at the shield plate window hole (3), only the back side of the head of the rat (7) can be suffered hurts of shock waves; the shield plate (2) is fixed, a pressure detector (9) and an explosion source (8) are arranged on the same horizontal level of the shield plate window hole (3), a distance between the explosion source (8) and the shield plate window hole (3) is equal with a distance between the explosion source (8) and the pressure detector (9); injuries are caused by initiation of an explosion, shock wave pressure data and head injury conditions of the big rat are recorded, the crania-cerebral explosion impact injury animal model is established. Defects that a vulnerated mechanism and a traumatic condition are difficult to be analyzed by a single factor in the existing technology are overcome. The method of establishing the crania-cerebral explosion impact injury animal model has the advantages that a structure of an experimental device is simple, bearing shock wave size conditions of the animal head can be reflected by data of the detector, and the injuries are caused by the head exposed purely.

Owner:CHENGDU MILITARY GENERAL HOSPITAL OF PLA

Sample post office

PendingCN114348665AGuaranteed safe storageConversion boostConveyorsElectric machineryStructural engineering

The invention belongs to the technical field of biology, particularly relates to a sample post office, and aims at solving the technical problem that exponential reduction of scientific and medical research values is finally caused by various problems that precious specimens are accidentally scrapped due to repeated freezing and thawing of existing biological specimens and the like. A motor protection bin is formed in one side of the motor set, a driving motor is installed in the motor protection bin and fixed to a motor installation plate, the bottom of the motor installation plate is fixed to the top of the body base plate, a plurality of air pipe connectors are fixed to the outer wall of the body base plate at equal intervals, and a rotating assembly is installed at the bottom of the body base plate. A first synchronous belt wheel is fixed to an output shaft of the driving motor, a second synchronous belt wheel is arranged on the top of the body base plate, and the second synchronous belt wheel is meshed with the first synchronous belt wheel. According to the invention, high efficiency of information and scientific research achievement conversion can be fully ensured while safe storage of biological samples is fully ensured, so that conversion of scientific research achievements is assisted.

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Owner:岑锦(上海)科技有限公司

Fluorescein derivative and synthetic method thereof

PendingCN114729352ASimple structureOrganic chemistryHydrolasesOxidative enzymeDehalogenase

The present disclosure relates to fluorescein derivatives and methods of synthesis of fluorescein derivatives. A method of synthesizing a fluorescein derivative includes performing a first reaction by using a toxic phenol derivative as a substrate, and reacting the toxic phenol derivative in a buffer solution by using a thermostable dehalogenase, a set of free radical scavenging enzymes, a set of polyphenol oxidase and an FADH2 generating system to obtain benzoquinone. The FADH2 generation system is capable of generating FADH2, which is a substrate for a thermostable dehalogenase. Furthermore, a second reaction is carried out between the derived benzoquinone and D-cysteine to obtain a fluorescein derivative capable of emitting light at a wavelength of 600-700 nm. Therefore, the fluorescein derivative can be used in various fields of medical research, drug research, other detection technologies and the like.

Owner:VIDYASIRIMEDHI INST OF SCI & TECH

3 results about "Medical research" patented technology

Method of establishing crania-cerebral explosion impact injury animal model

Sample post office

Fluorescein derivative and synthetic method thereof

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