Method of establishing crania-cerebral explosion impact injury animal model

A technology of explosive impact and animal models, applied in the field of medical research, to achieve the effect of simple structure of the experimental device and prevention of heat wave burns

Inactive Publication Date: 2013-05-15
CHENGDU MILITARY GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the defect that the existing animal model of craniocerebral blast injury is difficult to single-factor analysis of the injury mechanism and the injury condition of craniocerebral blast injury, and to provide an experimental device with simple structure and simple head exposure. , the detector data can reflect the size of the shock wave that the animal's head is subjected to, and the method of establishing the animal model of craniocerebral blast injury

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The method for establishing the animal model of craniocerebral blast injury in this example is as follows: Figure 1 and Figure four As shown, the rat 7 is fixed on the shielding plate 2 with the window hole 3, and the back side of the head of the rat 7 is aligned with the window hole 3 of the shielding plate, so that only the back side of the head of the rat 7 can be damaged by the shock wave; The adjustment hole 4 corresponds to the shielding plate window hole 3; the shielding plate 2 is fixed, and the pressure detector 9 and the explosion source 8 are placed on the same horizontal plane as the shielding plate window hole 3, so that the explosion source 8 is far from the shielding plate window hole 3 and the pressure detector 9 The distances are equal; the detonation causes injury, records the shock wave pressure data and the head injury of rats, and establishes an animal model of craniocerebral blast injury.

[0021] In this example, the explosion source is a paper...

Embodiment 2

[0024] The method for establishing the animal model of craniocerebral blast injury in this example is as follows: Figure II , Figure three and Figure four As shown, the shielding plate 2 is one side of the shock wave shielding box 1, and can be opened as the shielding door of the shock wave shielding box 1; there is a window 3 on the shielding door, and rats 7 are fixed on the shielding door, and 7 rats The back side of the head is aligned with the shielding door and window hole 3, so that only the back of the head of the rat 7 can be damaged by the shock wave; the appropriate adjustment hole 4 is selected to correspond to the shielding plate window hole 3; a pressure detector 9 is placed on the same level as the shielding door and window hole 3 and the explosion source 8, so that the distance from the explosion source 8 to the shielding door window hole 3 and the pressure detector 9 is equal; detonation causes injury, records the shock wave pressure data and the head inju...

Embodiment 3

[0028] The method for establishing the animal model of craniocerebral blast injury in this example is the same as that in Example 2 except that the source of the explosion is a shock wave generating device.

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Abstract

The invention relates to a method of establishing a crania-cerebral explosion impact injury animal model in the medical research field. The method of establishing the crania-cerebral explosion impact injury animal model is characterized in that a big rat (7) is fixed on a shield plate (2) with a window hole (3), a back side of a head of the big rat (7) is aligned at the shield plate window hole (3), only the back side of the head of the rat (7) can be suffered hurts of shock waves; the shield plate (2) is fixed, a pressure detector (9) and an explosion source (8) are arranged on the same horizontal level of the shield plate window hole (3), a distance between the explosion source (8) and the shield plate window hole (3) is equal with a distance between the explosion source (8) and the pressure detector (9); injuries are caused by initiation of an explosion, shock wave pressure data and head injury conditions of the big rat are recorded, the crania-cerebral explosion impact injury animal model is established. Defects that a vulnerated mechanism and a traumatic condition are difficult to be analyzed by a single factor in the existing technology are overcome. The method of establishing the crania-cerebral explosion impact injury animal model has the advantages that a structure of an experimental device is simple, bearing shock wave size conditions of the animal head can be reflected by data of the detector, and the injuries are caused by the head exposed purely.

Description

technical field [0001] The invention relates to the field of medical research, in particular to a method for establishing an animal model of craniocerebral blast injury. Background technique [0002] Explosive weapons are gradually becoming the main weapons of destruction in modern high-tech local wars. It is of great practical significance to strengthen the study of their injury characteristics and treatment, especially the treatment of blast trauma to the brain. Research on blast injury usually focuses on the lungs, chest, and abdomen. There are few research literatures on blast injury to the brain, and there is no mature and stable animal model of blast injury to the brain. [0003] In the current international literature reports on animal models of craniocerebral blast injury, no matter what kind of explosion source is used, the protection of the trunk and limbs is not involved. It is a systemic injury model, which makes the model complex and difficult to analyze the inj...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61D1/00
Inventor 顾建文程敬民马原
Owner CHENGDU MILITARY GENERAL HOSPITAL OF PLA
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