Method of Treating Cancer With Atpenin A5 Derviatives

a technology of atpenin and derviatives, applied in the field of new compositions and methods for the treatment of cancer, can solve the problems of in vivo studies that do not achieve the effect of success, and all suffer from low potency

Inactive Publication Date: 2021-04-01
UNIV OF ROCHESTER MEDICAL CENTER +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a method for treating cancer cells using a composition containing an Apenin 5 derivative. The Apenin 5 derivative can be selected from a group of compounds that have specific structures and can be administered through various routes such as oral, injection, or rectal. The method involves contacting the cancer cell with the Apenin 5 derivative, which can inhibit the growth of cancer cells and has potential to treat prostate cancer cells. The composition can also contain pharmaceutically acceptable carriers, excipients, buffers, or salts. The invention also includes a molecule with a specific formula that can be used for treating cancer cells. Overall, the invention provides a novel approach for treating cancer cells and has potential to improve the effectiveness of cancer treatment.

Problems solved by technology

Several CII inhibitors are known, but all suffer from low potency.
Atpenin A5 has been shown to inhibit the growth of cancer cells in vitro but this success does not translate to in vivo studies.

Method used

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Examples

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Embodiment Construction

[0038]While the making and using of various embodiments of the present invention are discussed in detail below, it should be appreciated that the present invention provides many applicable inventive concepts that can be embodied in a wide variety of specific contexts. The specific embodiments discussed herein are merely illustrative of specific ways to make and use the invention and do not delimit the scope of the invention.

[0039]To facilitate the understanding of this invention, a number of terms are defined below. Terms defined herein have meanings as commonly understood by a person of ordinary skill in the areas relevant to the present invention. Terms such as “a”, “an” and “the” are not intended to refer to only a singular entity, but include the general class of which a specific example may be used for illustration. The terminology herein is used to describe specific embodiments of the invention, but their usage does not limit the invention, except as outlined in the claims.

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PUM

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Abstract

The present invention includes molecules, composition, and methods for making and using a molecule having the formula (I), wherein R′ is selected from H, methoxy, or methoxymethyl; X is selected from H, OH, methoxy, or methoxymethyl or O—O methoxymethyl; Y is O; and R″ is selected from H, OH, 2-furan, ethyl, propyl, pentyl, hexyl, heptyl, octyl, nonly, decyl, or dodecyl, that are saturated or unsaturated.

Description

STATEMENT OF FEDERALLY FUNDED RESEARCH[0001]This invention was made with government support under R01-HL071158 awarded by the National Institutes of Health. The government has certain rights in the invention.CROSS-REFERENCE TO RELATED APPLICATIONS[0002]None.TECHNICAL FIELD OF THE INVENTION[0003]The present invention relates in general to the field of novel compositions and methods for the treatment of cancer, and more particularly, novel Atpenin A5 derivatives for the treatment of, e.g., prostate cancer.BACKGROUND OF THE INVENTION[0004]Without limiting the scope of the invention, its background is described in connection with treatments for prostate cancer.[0005]Mitochondrial respiratory complex II (CII), also known as succinate dehydrogenase (SDH) or succinate-coenzyme Q reductase (SQR), is a 124 kDa protein complex located in the inner membrane of mitochondria.[1] CII forms part of the electron transport chain (ETC) as well as being implicated in succinate signaling and substantia...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/44
CPCA61K31/44C07D405/06C07D213/69
Inventor TRIPPIER, PAULBROOKES, PAUL
Owner UNIV OF ROCHESTER MEDICAL CENTER
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