Histotripsy therapy systems and methods for the treatment of brain tissue

a technology of brain tissue and histopathology, applied in the field of histopathology therapy systems and methods for the treatment of brain tissue, can solve the problems of high cost, insufficient mrgfus treatment time, and inability to improve the functional outcome of ich survivors

Active Publication Date: 2018-06-07
RGT UNIV OF MICHIGAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides an ultrasonic treatment device that can deliver therapeutic energy to specific areas of the brain with minimal invasiveness compared to other methods such as surgery. It uses a special type of probe called a sonde that transmits high-frequency waves into the brain's blood vessels. This causes tiny bubbles to form around them when they hit certain parts of the brain. These bubble clouds are then released over time causing damage to nerves and muscles. Ultrasound technology has been developed to use this method to help reduce these damaging effects.

Problems solved by technology

The technical problem addressed by this patent is how to effectively treat large hematomas caused by histoplasma infarction using advanced techniques such as sonothrometry, cryoablative therapies, and neurosurgery.

Method used

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  • Histotripsy therapy systems and methods for the treatment of brain tissue
  • Histotripsy therapy systems and methods for the treatment of brain tissue
  • Histotripsy therapy systems and methods for the treatment of brain tissue

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Embodiment Construction

[0032]Histotripsy is a noninvasive, cavitation-based therapy that uses very short, high-pressure ultrasound pulses to generate a dense, energetic, lesion-producing bubble cloud. This Histotripsy treatment can create controlled tissue erosion when it is targeted at a fluid-tissue interface and well-demarcated tissue fractionation when it is targeted within bulk tissue. Additionally, Histotripsy has been shown to be capable of fragmenting model kidney stones using surface erosion that is mechanistically distinct from conventional shockwave lithotripsy (SWL). Histotripsy therapy can be guided and monitored using ultrasound B-mode imaging in real-time, since 1) the cavitating bubble cloud appears as a temporally changing hyperechoic region in B-mode imaging, allowing the treatment to be precisely targeted, and 2) the echogenicity of the targeted region decreases as the degree of tissue fractionation increases, which can be used as a way of monitoring lesion production (image feedback) in r

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Abstract

A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

Description

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Claims

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Application Information

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Owner RGT UNIV OF MICHIGAN
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