The medicinal composition for treating hyperplasia of prostate includes two separately packed components. The component A is prepared with 15 kinds of Chinese medicinal materials, including lysimachia, Japanese felt fern frond, patrinia, etc. The component B is prepared with 5 kinds of Chinese medicinal materials, including pearl, pangolin scales, amber, etc. clinical application shows that the medicinal composition has obvious curative effect on hyperplasia of prostate, clinical use safety and no toxic side effect.