The invention provides an operation cabinet for a laboratory. The operation cabinet comprises a working cabinet, a supporting frame group, a top cabinet and a control mechanism, wherein the top cabinet is mounted above the working cabinet through the supporting frame group; a first observation window and a second observation window are movably mounted on the supporting frame group; a first driving device, a second driving device, a third driving device and a fan are mounted in the top cabinet; the first driving device is in drive connection with the first observation window; the second driving device is in drive connection with the second observation window; the third driving device is in drive connection with a commodity shelf; a plurality of air guide holes are formed in the bottom of the commodity shelf; each air guide hole is communicated with a fan air inlet through a pipeline; a fan air outlet is connected with an air outlet pipe; a filter screen is mounted in the air outlet pipe; the control mechanism comprises a control device, a gravity sensing device, a light ray emitter, a light ray receiver and a control switch. According to the operation cabinet for the laboratory, the internal environment of the laboratory and the health of a human body can be effectively protected.