The invention relates to a method for preventing and/or treating iron overload through combining chlorophyll extracts and deferasirox. The chlorophyll extracts are preferably silkworm excrement extracts. The chlorophyll extracts can relieve the iron-deficiency anemia, and can also reduce the iron content in the body, so that the excessive iron removal treatment is avoided; the iron content in the body is reduced; meanwhile, the liver and kidney injury due to iron overload can also be relieved and restored; in addition, no obvious side effects exist. The chlorophyll extracts and the deferasirox are used in a combined way; the curative effect of the deferasirox can be improved, so that the treatment period of singly using the deferasirox can be shortened; the excessive iron removal treatment is avoided; the compliance of a patient is improved; the untoward effect risk after the long-time medication is reduced; the economical burden of the patient is greatly reduced.