Medicine composition and purpose thereof

[0038] Example 1. Iron removal effect of silkworm sand extract

[0039] 80 Kunming mice, half male and half female, were randomly divided into normal control group, positive control group, high-dose silkworm sand extract group and silkworm sand extract low-dose group, with 20 mice in each group, half male and half male. Except for the normal group, the mice in other groups were injected with iron dextran by intraperitoneal injection of 100 mg / kg once a week for 10 consecutive weeks to establish the iron overload mouse model. From the date of modeling, each group was given 1 gavage per day, among which: the normal control group was given 1 ml of normal saline, the positive control group was given 1 ml of normal saline, and the high-dose silkworm sand extract group was given silkworm sand extract at 80 mg / kg 1 ml of silkworm sand extract aqueous solution, and the low-dose group of silkworm sand extract was given 1 ml of silkworm sand extract aqueous solution at 40 mg / kg. ) l

[0044] Example 2. Clinical iron removing effect of silkworm sand extract

[0045] In order to prove the therapeutic effect of silkworm sand extract, the patients with iron overload were given silkworm sand extract to observe.

[0046] ⑴ General information

[0047] Thirty patients with iron overload due to long-term blood transfusion were selected, including 19 males and 11 females, aged 18-69 years, including 16 severe aplastic anemia (SAA) and 9 thalassemia major. There were 5 cases of osteoproliferative syndrome (MDS), and the liver and kidney functions were normal before treatment. When the SF level of the patients exceeded 1000μg / L, the silkworm sand extract was started to remove iron.

[0048] ⑵ treatment method

[0049] Each time, 4 tablets of silkworm sand extract were taken orally, 1 hour after meals, and tea was avoided, 3 times a day, 4 weeks as a course of treatment, and the treatment was 3 courses of treatment.

[0050] (3) Observation indicators

[0051] Pati

[0060] Example 3. Silkworm sand extract protects liver and kidney injury caused by iron overload

[0061] 80 Kunming mice, half male and half female, were randomly divided into normal control group, positive control group, high-dose silkworm sand extract group and silkworm sand extract low-dose group, with 20 mice in each group, half male and half male. Except for the normal group, the mice in other groups were injected with iron dextran by intraperitoneal injection of 100 mg / kg once a week for 10 consecutive weeks to establish the iron overload mouse model. From the date of modeling, each group was given 1 gavage per day, among which: the normal control group was given 1 ml of normal saline, the positive control group was given 1 ml of normal saline, and the high-dose silkworm sand extract group was given silkworm sand extract at 80 mg / kg The low-dose group of silkworm sand extract was given 1 ml of silkworm sand extract aqueous solution at 40 mg / kg. After the treatment, b