The invention provides application of esomeprazole and trimebutine maleate, bismuth pectin as well as clarithromycin in a combined drug for treating upper gastrointestinal tract ulcer, and simultaneously provides the combined drug of esomeprazole and trimebutine maleate, bismuth pectin as well as clarithromycin. The components of the combined drug preparation provided by the invention are matchedwith each other and exert actions from different angles, and has better treatment effect on upper gastrointestinal tract ulcer.