Thiazole derivative containing aminoglucose and coumarin and preparation method and uses thereof

[0026] Embodiment 1, a kind of thiazole derivative containing glucosamine and coumarin molecules, its molecular formula is as follows:

[0027]

[0028] Wherein, the R is selected from H-; 6-CH 3 -6-OCH 3 -8-OCH 3 -;6,8-Br 2 -;6-NO 2 -; 6-Cl-; 6-Br-; 6-F-; 8-OC 2 h 5 - 7-OCH 3 -; 6-I-; 5-F-; 8-NO 2 -;6,8-Cl 2 -;6,8-I 2 -; 5-F-; 6-Cl-8-Br-.

[0029] Embodiment 2, a kind of synthetic method of the thiazole derivative containing amino sugar and coumarin molecule as described in embodiment 1, its steps are as follows:

[0030] (1) 2-Deoxy-2-isothiocyanate-1,3,4,6-tetra-O-benzyl- β -D-glucopyranose preparation: 2-deoxy-2-amino-1,3,4,6-tetra-O-benzyl- β -D-pyranose hydrochloride, carbon disulfide and triethylamine are reacted, and then reacted with p-toluenesulfonyl chloride to obtain 2-deoxy-2-isothiocyanate-1,3,4,6-tetra-O- Benzyl- β -D-glucopyranose; reaction with acetonitrile as solvent, 2-deoxy-2-amino-1,3,4,6-tetra-O-benzyl- β - The molar ratio of D-pyranose hydrochloride to carbon disulfide, triethylamine and p-toluenesulfonyl chloride is 1:1:3:1, the reaction temperature is 0°C, and the reaction time is 1 hour.

[0031] (2) N -(1,3,4,6-tetra-O-benzyl-2-deoxy- β -D-glucopyranose-2-yl)thiourea preparation: in 2-deoxy-2-isothiocyanate-1,3,4,6-tetra-O-benzyl- β -D-Glucopyranose is passed into ammonia gas, and the

[0033] Embodiment 3, a kind of synthetic method of the thiazole derivative containing glucosamine and coumarin molecule as described in embodiment 1, its steps are as follows:

[0034] (1) 2-Deoxy-2-isothiocyanate-1,3,4,6-tetra-O-benzyl- β -D-glucopyranose preparation: 2-deoxy-2-amino-1,3,4,6-tetra-O-benzyl- β -D-pyranose hydrochloride, carbon disulfide and triethylamine are reacted, and then reacted with p-toluenesulfonyl chloride to obtain 2-deoxy-2-isothiocyanate-1,3,4,6-tetra-O- Benzyl- β -D-glucopyranose; reaction with acetonitrile as solvent, 2-deoxy-2-amino-1,3,4,6-tetra-O-benzyl- β - The molar ratio of D-pyranose hydrochloride to carbon disulfide, triethylamine and p-toluenesulfonyl chloride is 1:1.3:3.5:1.3, the reaction temperature is 0°C, and the reaction time is 2 hours.

[0035] (2) N -(1,3,4,6-tetra-O-benzyl-2-deoxy- β -D-glucopyranose-2-yl)thiourea preparation: in 2-deoxy-2-isothiocyanate-1,3,4,6-tetra-O-benzyl- β -D-Glucopyranose is passed into ammonia gas,