Biocompatible dialysis fluids containing icodextrins

A technology of icodextrin and peritoneal dialysis, applied in dialysis systems, peritoneal dialysis, medical preparations containing active ingredients, etc., can solve problems such as pain and peritoneal cell cytotoxicity

Active Publication Date: 2006-05-03
BAXTER INT INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, low pH may cause pain when infused in some patients and is cytotoxic

Method used

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  • Biocompatible dialysis fluids containing icodextrins

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Composition of the glucose polymer chamber

[0048] Icodextrin (g / L) 100.0-220.0

[0049] Calcium chloride dihydrate (mEq / L) 5.0-10.0

[0050] Magnesium chloride hexahydrate (mEq / L) 0.5-2.0

[0051] HCl, for adjusting pH from 2.5 to 5.0

[0052] The composition of the buffer chamber

[0053] Sodium chloride (mEq / L) 50.0-150.0

[0054] Sodium Lactate (mEq / L) 50.0-120.0

[0055] Sodium bicarbonate and / or histidine, to adjust the pH to 8.0 to 9.0

Embodiment 2

[0057] Composition in the glucose polymer compartment (large compartment)

[0058] Icodextrin (g / L) 121

[0059] Sodium chloride (g / L) 4.22

[0060] Calcium chloride dihydrate (g / L) 0.40

[0061] Magnesium chloride hexahydrate (g / L) 0.08

[0062] Sodium Lactate (g / L) 3.50

[0063] pH about 5.0 to about 5.4

[0064] The composition of the buffer room (cabin)

[0065] Sodium chloride (g / L) 7.42

[0066] Sodium lactate (g / L) 6.15

[0067] Sodium bicarbonate (g / L) 0.58

[0068] pH about 8.2 to about 8.7

[0069] Icodextrin and Ionic Composition in Mixed Solutions

[0070] Icodextrin (g / dL) 4.0-10.0

[0071] Calcium (mEq / L) 0.5-4.0

[0072] Magnesium (mEq / L) 0.25-2.0

[0073] Sodium (mEq / L) 120.0-135.0

[0074] Chlorine (mEq / L) 90.0-110.0

[0075] Lactate (mEq / L) 30.0-45.0

[0076] Bicarbonate or Histidine (mM) NMT 5.0

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Abstract

The present invention discloses glucose polymer-based solutions and methods for their preparation, which solutions can be used in medical treatments such as dialysis treatments. The glucose polymer-based solution preferably comprises a first solution containing icodextrin having a pH in the range of about 1.5 to about 5.0 and a buffer solution in the pH range of from about 7.0 to about 12.0, constructed and arranged to allow the glucose polymer-based solution to Mixed before infusing into patient. The glucose polymer-based solutions of the present invention can be prepared at physiological pH with minimal glucose degradation products.

Description

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Claims

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Application Information

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Owner BAXTER INT INC
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