Dual mode remote ischemic preconditioning devices and methods

Active Publication Date: 2013-07-18
INFARCT REDUCTION TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0011]Accordingly, it is an object of the present invention to overcome these and other drawbacks of the prior art by providing novel methods and automatic devices to fully trigger innate ischemic tolerance via application of remote ischemic preconditioning therapy in a diverse group of patients including those with a variety of preexisting conditions, which may otherwise reduce the efficacy of this procedure.

Problems solved by technology

There is insufficient available energy to maintain cell membrane pump activity, anti-oxidant defenses, pH and calcium homeostasis, and mitochondrial integrity.
These and other consequences of ischemia inevitably lead to cell death, unless blood flow is restored.
Though reperfusion with oxygenated blood is essential for any tissue salvage, the sudden influx of oxygen leads to the formation of reactive oxygen species.
This leads to a rapid influx of small molecules, mitochondrial swelling and subsequent cell death.
Activation of complex defensive response triggered by an ischemic preconditioning stimulus may be impaired in some categories of patients such as elderly or diabetics.
Prior art devices have a predetermined and usually fixed preconditioning treatment protocol, which may not account for particular needs of such special patient groups.

Method used

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  • Dual mode remote ischemic preconditioning devices and methods
  • Dual mode remote ischemic preconditioning devices and methods
  • Dual mode remote ischemic preconditioning devices and methods

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Example

[0028]The following description sets forth various examples along with specific details to provide a thorough understanding of claimed subject matter. It will be understood by those skilled in the art, however, that claimed subject matter may be practiced without one or more of the specific details disclosed herein. Further, in some circumstances, well-known methods, procedures, systems, components and / or circuits have not been described in detail in order to avoid unnecessarily obscuring claimed subject matter. In the following detailed description, reference is made to the accompanying drawings, which form a part hereof. In the drawings, similar symbols typically identify similar components, unless context dictates otherwise. The illustrative embodiments described in the detailed description, drawings, and claims are not meant to be limiting. Other embodiments may be utilized, and other changes may be made, without departing from the spirit or scope of the subject matter presented

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Abstract

A dual mode automatic device for delivery of remote ischemic preconditioning treatment includes a cuff and a controller configured to deliver a first regular treatment protocol or a second extended treatment protocol. Switching to an extended treatment protocol may be done by an operator for selected groups of patients such as elderly or patients with diabetes. Automatic determination of the best mode is also disclosed. Optimal delivery of remote ischemic preconditioning treatment in this individualized patient-specific manner provides strong ischemic protection to a greater number of patients.

Description

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Claims

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Application Information

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Owner INFARCT REDUCTION TECH
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