Polyhedral oligomeric silsesquioxane (POSS)-based bioactive hybrid glass as a scaffold for hard tissue engineering

a bioactive glass and polyhedron technology, applied in the field of hybrid bioactive glass, can solve the problems of complex nanostructures that are difficult to achieve synthetically, the manner in which to design and fabricate bio-inspired bulk materials remains a grand challenge, and the exact tissue or organ-like complex nanostructures of bio-inspired materials of the future are not necessarily identical

Inactive Publication Date: 2015-10-22
THE UNIVERSITY OF AKRON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to a new type of biological material called silicon-oxygen-silicate (SOS) glass that can be used for various applications such as building materials, medical devices, and other industries. These glasses have unique properties like flexibility, strength, and durability. They are made by combining different types of molecules together with a chemical reaction process. This results in a more efficient production method compared to existing methods.

Problems solved by technology

This patent describes how to create strong and flexible materials from naturally occurring materials called hyaluronan and collagen. They can also contain other types of small molecules like calcium phosphate, which helps them grow and differentiate into specific structures. By combining these two components together, they can form stronger materials with improved strength and flexibility.

Method used

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  • Polyhedral oligomeric silsesquioxane (POSS)-based bioactive hybrid glass as a scaffold for hard tissue engineering
  • Polyhedral oligomeric silsesquioxane (POSS)-based bioactive hybrid glass as a scaffold for hard tissue engineering
  • Polyhedral oligomeric silsesquioxane (POSS)-based bioactive hybrid glass as a scaffold for hard tissue engineering

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Experimental program
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Effect test

examples

Materials

[0088]Octavinyloctasila-sesquioxane (PSS-Octavinyl substituted), triethoxysilane, Alizarin Red S, Platinum (0)-1,3-divinyl-1,1,3,3-tetramethyldisiloxane complex solution in xylene, and other chemicals were purchased from SigmaeAldrich (St. Louis, Mo.).

Synthesis of POSS-Derived Precursor

[0089]0.15 mL of Pt catalyst was added to a stirred mixture of octavinyloctasilasesquioxane (0.5 g, 789.84 μmol) and triethoxysilane (2.6 g, 15.8 mmol) over 10 min. The temperature of the reaction mixture was controlled not exceed 30° C. The solution was then heated to 90° C. for 6 h, cooled down and stirred at room temperature overnight. The excess triethoxysilane was removed in vacuo at 50° C. to afford light yellow oil (1.12 g, yield: 77%).

POSS-Derived Hybrid Glass (PHG) Preparation

[0090]The PHG was prepared following the sol-gel method by incorporation of calcium alkoxide during the polycondensation process of the precursors. In a typical synthesis, POSS-derived precursor and 1.9 g (2 mmol)

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Abstract

A hybrid bioactive glass comprising a plurality of POSS-cages each having at least one flexible arm radiating from an Si atom of the POSS-cage, each POSS-cage being covalently linked to another POSS-cage through an Si—O—Si linkage between two flexible arms. A method of forming a hybrid bioactive glass comprising the steps of providing a plurality of POSS-cages, each having at least one reactive flexible arm radiating from an Si atom detailed by —X—Si[R1,2,R3], wherein X is an arm extension located between the Si—O—Si linkage and an Si atom of the POSS-cage, wherein R1, R2 and R3 are also the same or different, and at least one of the R1, R2 and R3 is an alkoxide, and reacting the plurality of POSS-cages through a sol-gel method to form a covalently-linked network and incorporating Ca+2 ions therein, the sol-gel process comprising hydrolysis and polycondensation reactions of the plurality of POSS-cages.

Description

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Claims

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Application Information

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Owner THE UNIVERSITY OF AKRON
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