Method for preparing three-dimensional porous bioactive glass

A bioactive glass, three-dimensional porous technology, applied in tissue regeneration, medical science, prosthesis, etc., to achieve excellent adsorption performance and improve the effect of sustained release of drugs

Inactive Publication Date: 2017-09-05
ZHEJIANG SCI-TECH UNIV
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AI Technical Summary

Benefits of technology

In this patented process, there was developed an improved way to make fine crystalline calcium phosphate (CaP) with specific sizes called mesoporous or micropores. These tiny holes allow cells to stick together easily while still being able to move freely through them. By loading certain types of Zeolites onto these small particles they were found to improve their effectiveness at delivering medications over longer periods of time compared to traditional methods like plaster castings. They could also serve as novel substitutes for autologuous tissue graft material.

Problems solved by technology

This patents discusses various technical problem addressed during current studies relating to replacing damaged areas (bone) found around humans due to environmental issues like pollution and disease risk associated with fossil fuel use. Natural sources of ceramism, including animal origins, provide promising alternatives because they offer better compatibility between them than existing substances. Additionally, combining multiple types of bioplasms into one construct may improve their effectiveness without causing damage to surrounding tissues while maintaining excellent physiology function.

Method used

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  • Method for preparing three-dimensional porous bioactive glass
  • Method for preparing three-dimensional porous bioactive glass
  • Method for preparing three-dimensional porous bioactive glass

Examples

Experimental program
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Embodiment

[0023] figure 1 Shown are the morphology changes of porous silicate nanosheets at different NaOH concentrations. When the NaOH concentration is 1mol / L, a uniform and ordered array of silicate nanosheets is formed on the conductive surface of the glass. The size of the silicate nanosheets is about 500nm, and the adjacent nanosheets are closely adjacent to each other, forming a channel with a size of about 400 nm, and the large-area nanosheets are closely arranged to form a porous silicate nanosheet array. When the NaOH concentration is 2mol / L, a uniform and orderly array of silicate nanosheets is still formed on the glass. At this time, the size of the silicate nanosheets is reduced to about 200nm, and the adjacent silicate nanosheets They are closely connected with each other to form pores with a size of about 100nm, and the large-area nanosheets are closely arranged to form a porous silicate nanosheet array; with the increasing concentration of NaOH, the size of the silicate

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Abstract

The invention discloses a method for preparing three-dimensional porous bioactive glass. The method comprises the following steps: preparing a three-dimensional porous silicate nanosheet array to serve as a main support material of the bioactive glass through a hydrothermal method; regulating the concentration and reaction time to regulate the particle size of macroporous silicate nanosheets and the size of the nanosheets; and supporting a microporous molecular sieve onto the silicate nanosheets through the hydrothermal method, thereby obtaining the three-dimensional porous bioactive glass of a hierarchical structure. The bioactive glass prepared by the method has a similar structure to that of a natural bone material. The microporous molecular sieve has a drug sustained release function, a composite structure and a functional bionics principle. Meanwhile, the bioactive glass has excellent biocompatibility, biological activity and drug sustained release function and can promote adhesion, proliferation and differentiation of cells on the surface of the bioactive glass. The three-dimensional porous ordered bioactive glass can serve as a new-generation bone substitution material and a biological scaffold material for bone repair.

Description

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Claims

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Application Information

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Owner ZHEJIANG SCI-TECH UNIV
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