The invention discloses a blast furnace smelting method of high-grade vanadium-titanium magnetite, and belongs to the technical field of steel and iron smelting. The blast furnace smelting method of the high-grade vanadium-titanium magnetite comprises the following steps: sinters and pellets are mixed for blast furnace smelting to obtain molten iron and slag; the sinters comprise raw materials ofvanadium-titanium magnetite concentrates, iron concentrates, activated lime and fuels; and the pellets are pelletized by the vanadium-titanium magnetite concentrates and bentonite. The method preparesthe sinters and the pellets by using high-iron low-titanium vanadium-titanium magnetite concentrates; the sinters and the pellets are added in the blast furnace smelting to greatly increase the use ratio of the vanadium-titanium magnetite; and through the measures of high air temperature and oxygen-enriched air blowing, under the condition of 20-25% of the TiO2 content in the slag, the reinforcedsmelting of the vanadium-titanium magnetite is realized, the production cost in the blast furnace iron smelting is reduced, the vanadium content of the molten iron is increased, and the comprehensiveutilization of the vanadium-titanium magnetite is efficiently realized.