3 results about "Computer simulation" patented technology

The invention provides a compound for targeted ubiquitinated degradation of Smad3. The compound for targeted ubiquitinated degradation of Smad3 is formed by connecting a compound shown in a formula (I) and an ubiquitin ligase E3 identifying ligand shown in a formula (II) through a Linker shown in a formula (III) for connecting the two. The invention constructs a compound which can be specifically combined with Smad3 to degrade Smad3 proteins in a targeted manner through ubiquitination by jointly applying computer virtual screening and a technology of target ubiquitinated degradation of proteins, and the compound is verified to be capable of degrading Smad3 in a targeted ubiquitinated manner. As Smad3 is the major known fibrosis-inducing signaling protein, the Protac theoretically has an anti-fibrosis effect. Moreover, the molecular weight of the compound is small, so that the Protac can get into or out of cells freely, and therefore, the compound is likely to become a novel drug for treating fibrosis. The compound not only has scientific value, but also has important social value.

Various embodiments of a system and method for creating and controlling a model of a sensor device for a computer simulation are disclosed. Sensor information specifying physical properties of the sensor device may be received, and a model of the sensor device may be automatically generated using the sensor information. An electrical circuit simulation may be performed using the model of the sensor device. The system and method may enable the user to interactively change the sensor device model during the simulation. The user may interact with a graphical user interface during the simulation to provide input specifying a change in one or more physical properties of the sensor device. In response to the user input, the model of the sensor device may be dynamically modified during the simulation to simulate the change in the one or more physical properties of the sensor device.

Techniques are disclosed pertaining to determining a level of proficiency of a user at a computer simulation through the use of a plurality of skill assessment tests. Each skill assessment test can test a respective skill for use in the computer simulation. The techniques can also be used to train a user for the computer simulation and/or to determine team composition using roles for use in the computer simulation. In some aspects, skill assessment tests may incorporate multiple iterations in including a first base line iteration and subsequent iterations that differ between user devices. In some embodiments, metrics that are indicative of a level of proficiency of the user can be made with respect to metrics of other users to determine a user's level of skill with respect to various groups of other users.