The invention discloses a course anomaly detection and safety protection method and device, equipment and a storage medium. The method comprises the steps: when the unmanned aerial vehicle is in a flight scene, acquiring magnetic compass associated data, at least one piece of real-time dynamic RTK associated data and gyroscope data; judging whether the magnetic heading of the unmanned aerial vehicle is abnormal or not according to the magnetic compass associated data, judging whether the RTK heading of the unmanned aerial vehicle is abnormal or not according to the at least one piece of RTK associated data, and judging whether the real-time fusion heading of the unmanned aerial vehicle is abnormal or not according to the gyroscope data and the magnetic heading; and if at least one of the magnetic heading, the RTK heading and the real-time fusion heading is determined to be abnormal, executing at least one safety protection measure. By using the technical scheme of the invention, accurate and stable course anomaly detection and safety protection of the unmanned aerial vehicle can be realized, timely and effective safety protection can be performed when the course is abnormal, and the flight safety of the unmanned aerial vehicle is improved.