The invention discloses a mailbox-based multi-processor communication method, device and system and a storage medium, and the method comprises the steps: receiving a data packet sent by a processor in a sending state based on the mailbox-based multi-processor communication method; if the transmission information of the data packet meets a preset read condition, sending a notification signal to a processor in a receiving state; receiving a reading signal sent by the processor in the receiving state for the notification signal; based on the synchronous FIFO principle, after the read signal is subjected to metastable state processing, the data packet is sent to the processor in the receiving state, data writing and data reading in the same clock domain are achieved, conversion between a binary code and a Gray code is avoided, the time sequence delay of cross-clock-domain communication is effectively solved, and the communication efficiency is improved. The communication efficiency is improved, and the design complexity is reduced.