The invention belongs to the technical field of chemical
drug analysis and particularly relates to an
analysis method for detecting related substances in
imidafenacin. The detection method adopts highperformance liquid
chromatography and comprises the
chromatography condition that a flowing phase A and a flowing phase B are adopted as a mixed flowing phase for
gradient elution, wherein the flowing phase A adopts a
phosphoric acid solution of
sodium 1-octanesulfonate; and the flowing phase B adopts
acetonitrile. By adopting the detection method, detected impurities are numerous, the retainingability of main components and all the impurities in a flowing phase
system is high, response is high, all the impurities can be separated effectively, and the related substances in the
imidafenacin can be monitored rapidly and accurately.