The invention discloses an interaction method and system of application programs and webpages and a storage medium. The method comprises the steps of initializing a WebView object; loading a local JavaScript code through an initialized WebView object; loading a local JavaScript code through the initialized WebView object; carrying an interactive interface on the WebView object; determining a callback method of the to-be-interacted information according to an interaction protocol name between the application programs and the webpages; and according to the interaction interface, executing a callback method of the to-be-interacted information through the local JavaScript code to obtain the to-be-interacted information. The data interaction between the application programs and the webpages isrealized based on the WebView technology, so that the application programs can acquire the interaction action information of the webpage ends in real time, the webpage ends can acquire the interactionaction information of the application programs in real time, the reliability is high, the real-time performance is high, and the invention can be widely applied to the technical field of data communication.