The invention relates to a space-borne microwave atmospheric sounding instrument, which comprises feed sources, calibration bodies, a motor, plane mirrors, parabolic reflectors, a scanning drive control module, multiplexers and receiver units. The motor is controlled by the scanning drive control module to drive the plane mirror to rotate. The plane mirrors reflect received electromagnetic wave signals to the parabolic reflectors in the form of plane waves by scanning the atmosphere and the calibration bodies. The parabolic reflectors realize secondary reflection to enable the plane waves to be reflected to the corresponding feed sources arranged opposite thereto. The multiplexers are used for separating the frequency of the electromagnetic wave signals received by the feed sources respectively. Each receiver unit comprises a plurality of receivers parallel with the output end of the corresponding multiplexer, and is used for receiving the electromagnetic wave signals matched with the frequency thereof. The space-borne microwave atmospheric sounding instrument has the advantages of being high in performance, high in integration, low in weight and low in power consumption.