1 results about "Significant difference" patented technology

The invention discloses a hydrophilic hollow silicon sphere as well as a preparation method and application thereof. The hydrophilic hollow silicon sphere is prepared by modifying the surface of a silicon-oxygen structured double-bond silicon sphere, which is formed by performing catalytic reaction on vinyltriethoxysilane and is used as a core, with glutathione, and etching a sphere center with hydrofluoric acid. Drug encapsulation and in-vitro simulated releasing experimental results show that compared with a hollow silicon sphere of a contrast group, the hollow silicon sphere prepared with the preparation method disclosed by the invention has a significant difference in drug loading and in-vitro releasing of camptothecin, so that the hydrophilic hollow silicon sphere prepared with the preparation method is relatively high in loading capacity and relatively good in controlled release effect. The hydrophilic hollow silicon sphere is simple in design; no reaction conditions such as high temperature and high pressure are needed; the particle size distribution of the silicon sphere is uniform; feasibility is provided for industrial production of the hydrophilic hollow silicon sphere; a new way is provided for researches on drug slow release carriers; the hydrophilic hollow silicon sphere has good social and economical benefits.