The invention discloses a chimonanthus nitens disease prevention liquid and an application method thereof. The chimonanthus nitens disease prevention liquid is prepared from, by weight, 40-60 parts ofchimonanthus nitens bark or stems, 15-25 parts of garlic, 18-22 parts of ginger, 16-24 parts of rock candy and a plurality of parts of water. The chimonanthus nitens disease prevention liquid of theinvention is safe to human and livestock, and has significant effect; after spraying with the chimonanthus nitens disease prevention liquid, the virus replication of tobacco plants infected with mosaic diseases and horse Y diseases is inhibited, leaves grow normally, chlorophyll is increased, photosynthesis is enhanced, leaf dry matter accumulation is increased, it is guaranteed that tobacco leaves grow mature, and no pesticide residues exist; and the chimonanthus nitens disease prevention liquid is suitable for all peasant households and units for tobacco planting and suitable for popularization.