Preparation method of targeted ferroferric oxide-porphyrin containing composite nanoparticles
A technology of composite nanoparticles and ferric oxide, which is applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problem of weak fluorescence signal intensity of photosensitizers and tumor tissue selection. The problem of low sexual uptake and high cumulative effect of photosensitizers can achieve the effect of inhibiting tumor metastasis, improving immunity and reducing diffusion
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[0026] Specific embodiment 1: This embodiment has a method for preparing targeted ferroferric oxide-porphyrin composite nanoparticles, which is specifically carried out according to the following steps:
[0027] 1. Using FeCl 3 ·6H 2 O prepares FeCl with a concentration of 0.1 mol / L 3 Solution using FeSO 4 ·4H 2 O prepares FeSO with a concentration of 0.1 mol / L 4 Solution
[0028] Under nitrogen protection and mechanical stirring conditions, according to Fe 3+ With Fe 2+ The molar ratio is 2:1, and 100mL FeCl with a concentration of 0.1mol / L 3 Solution and 50mL FeSO with a concentration of 0.1mol / L 4 Mix the solution to get FeCl 3 And FeSO 4 Then, use hydrochloric acid with a concentration of 1mol / L to adjust the pH to 5, and then add an aqueous ammonia solution with a mass concentration of 25% until the mixed solution appears black precipitation, and then continue to stir for 1h to obtain a solid-liquid mixture;
[0029] Under the action of an external magnetic field, the uppe
Example Embodiment
[0035] Specific embodiment two: This embodiment is different from specific embodiment one in that step one uses a mixture of twice distilled water and ethanol with a volume ratio of twice distilled water and ethanol of 1:1 for washing. Others are the same as the first embodiment.
Example Embodiment
[0036] Specific embodiment three: This embodiment is different from specific embodiment one in that 100 mL of double distilled water is added in step two. Others are the same as the first embodiment.
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