Notoginsen triterpenes microcapsule and preparation method thereof
A technology of Panax notoginseng saponins and microcapsules, which is applied in the field of Panax notoginseng saponins microcapsules and its preparation, can solve the problems of undiscovered research reports and patent applications of Panax notoginseng saponins microcapsules, and improve patient compliance, Improved taste and improved bioavailability
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[0018] Example 1
[0019] Preparation of Panax Notoginseng Total Saponins Microcapsules by Single Coagulation Method, Formula:
[0020] Panax notoginseng saponins (superfine powder) 10g
[0021] Gelatin 80g
[0022] Preparation process: First, the total saponins of Panax notoginseng are superfinely treated by the superfine pulverization method, so that the particle size is less than 25 μm and the content is uniform. Under the condition of 100,000 grades, add the total saponins of notoginseng to 2400ml of 60°C without salt water, carefully adjust the pH to 7.2~7.8 with 0.01% NaOH, add gelatin at 37°C, and keep the temperature at 37°C. Stir to dissolve, add 10% acetic acid dropwise to pH 3.5-3.8, and place the reactor in a water bath at 50°C for 45 minutes to keep warm and stir. Add sodium sulfate solution (diluent) dropwise, observe under the microscope until the capsules are formed, pour it into the stirring diluent immediately, after gelling and sedimentation, pour off the supernata
Example Embodiment
[0023] Example 2
[0024] Preparation of Panax Notoginseng Total Saponins Microcapsules by Complex Coagulation Method, Formula:
[0025] Panax notoginseng saponins (particle size <10μm) 10g
[0026] Gelatin 60g
[0027] Pectin 40g
[0028] Preparation process: Under the condition of 100,000 grades, the total saponins of notoginseng are first added to 96ml ethyl acetate, and the mixture is stirred thoroughly and set aside. Take appropriate amount of pectin and panax notoginseng saponins to make colostrum, and dilute the colostrum with 4800ml of 3% pectin solution to make O / W emulsion. In addition, the gelatin was dissolved into a 4800ml gelatin solution, the pH was adjusted to 8 with 10% sodium hydroxide, and the two-liquid reactor was placed in a water bath at 50°C and stirred for 45 minutes. Adjust the mixed solution to pH 4.05 with 10% acetic acid solution, continue to stir for 5 minutes, dilute with twice the volume of water, let cool to about 28°C, then transfer to an ice water
Example Embodiment
[0029] Example 3
[0030] Preparation of panax notoginseng saponins microcapsules by solvent-non-solvent method, formula:
[0031] Panax notoginseng saponins (particle size <10μm) 10g
[0032] Cellulose butyl acetate 240g
[0033] Butanone 6000g
[0034] Preparation process: First dissolve cellulose acetate butyl ester in 6000ml methyl ethyl ketone under the condition of 100,000 grade, and pay attention to make it completely dissolve, set aside. Then, the total saponins of notoginseng were added to it, and the reactor containing the reaction liquid was placed in a water bath at 55° C. and stirred for 45 minutes. The non-solvent isopropyl ether is slowly added under stirring, and the suspended core material is wrapped into microcapsules when the coacervate phase separation occurs. Slowly cool to room temperature, separate the microcapsules by centrifugation, wash with isopropyl ether, and dry in vacuum to obtain the required microcapsules.
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