2 results about "Benzonitrile" patented technology

The invention discloses a preparation method of 3-fluoro-4-cyanophenol, which belongs to the field of organic chemical synthesis. 2,4-difluorobenzonitrile is adopted to prepare 2-fluoro-4-alkoxy benzonitrile by virtue of substitution reaction, and then 3-fluoro-4-cyanophenol can be obtained by virtue of hydrolytic reaction. By adopting the preparation method, the production cost can be reduced, the product purity and yield can be improved, and the preparation method has the advantages of ease in obtaining raw materials, mild reaction conditions, simplicity in operation, and suitability for industrialized mass production.

The invention provides a preparation method of a citalopram intermediate 4-(4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl) benzonitrile. The method provided by the invention has the advantages of cheap and easily available raw materials, short reaction steps, high yield, simple post-treatment, easy operation and the like, reduces the cost, has certain technical advantages,and is suitable for large-scale industrial production.