The present invention describes a bioinformatic method that can be used in the
estimation of an individual's susceptibility to
cancer through an evaluation of that individual's personal
genome sequence. More specifically, this invention is a
continuation-in-part of the methodology described in
patent application Ser. No. 14 / 154,303 for the
early detection of
cancer. Said method is based upon an analysis of the structure of the repetitive
DNA sequences surrounding and within the various
cancer-linked regions of the individual's
genome being evaluated. Said analysis of said individual's
genome is then compared to the same analysis conducted for one or more reference genomes and / or genes for which
cancer susceptibility has been previously determined. Said analysis can also be used to estimate the respective likelihoods that each cancer-linked genomic region will be damaged in the potential formation of a tumor. This patient-specific analysis can then be used in the economical design of locus-specific monitoring for early genetic damage as part of pre-cancer genetic screening.