The invention relates to the technical field of pest control, in particular to a biological prevention and control method for disease and insect damage to lonicera japonica. The method comprises the following steps: stacking plant organic materials in a stack yard, spraying water to the materials, and uniformly stirring, so as to obtain wet materials, adding a biological inoculant into the wet materials, uniformly stirring, adjusting the humidity, performing accumulating fermentation, stirring once every other day, adding potassium humate, diammonium hydrogen phosphate and potassium sulfate after fermentation is accomplished, adding water, uniformly stirring, adding coal ash, adjusting the materials into homogenate, drying, performing granulation, and applying obtained granules into a lonicera japonica field. The method solves the problems of root rot of lonicera japonica and grub attack, does not cause chemical fertilizer excessive heavy metal residual, improves the production value of lonicera japonica, and has excellent economic and social benefits.