The invention discloses a ureas derivative and application thereof in preventing and treating inflammation. R1, R2 and R3 are respectively and independently selected from H, F or NO2. The in vitro activity measuring result shows that the compound has 5-lipoxygenase inhibitory activity and prostaglandin E synthetase inhibitory activity and can be used as a medicine for treating inflammation and forfurther carrying out thorough and extensive study, and the inflammation can be gynecology inflammation, hepatitis, myocarditis, encephalitis, nephritis, pneumonia, trachitis, pharyngitis, periodontitis, gastritis, enteritis and the like.