The invention relates to a composite antibody extract, a preparation method and applications thereof. The preparation process of the composite antibody extract comprises: preparing a composite antigencontaining facial pathogenic bacteria, carrying out strengthening immunization on chicken, obtaining immunized eggs, separating and purifying the egg yolks of the immunized eggs to obtain a crude extract, and continuously separating and purifying to obtain an extract containing a composite antibody against the facial pathogenic bacteria. According to the present invention, the prepared compositeantibody extract has characteristics of high stability, strong antibody specificity and good safety, and can effectively resist the infestation of facial pathogenic bacteria, effectively resist bacteria and remove acne, and reduce the recurrence of acne.