The invention provides a crystalline state
Lesinurad intermediate and a preparation method thereof. The invention discloses a crystalline state
Lesinurad intermediate (II) and a preparation method thereof. The result of
differential scanning calorimetry on the crystalline state
Lesinurad intermediate (II) shows that peaks appear in a range of 98 to 102 DEG C. The result of
powder X-
ray diffraction shows that characteristic peaks appear at (2[theta]): 8.8+ / -0.2 degrees, 10.5+ / -0.2 degrees, 10.6+ / -0.2 degrees, 15.6+ / -0.2 degrees, 22.1+ / -0.2 degrees, and 22.9+ / -0.2 degrees. The
solid of crystalline state Lesinurad intermediate (II) is obtained for the first time, the purity is high, the operation of the
crystallization method is simple,
column chromatography purification is not needed, the method is suitable for industrial production; the obtained crystalline state
solid has stable properties, thus storage, transportation, and feeding operation become convenient, and the purity of final product Lesinurad prepared from the intermediate (II) is high.