The invention discloses an immunoadsorption blood purification material and a preparation method thereof. The preparation method comprises the following steps: activating a solid-phase carrier by using CDI, and further covalently coupling ligand molecules with amino groups to obtain the immunoadsorption material. The method is simple in process, compared with an immunoadsorption carrier prepared from the same raw materials in the prior art, the immunoadsorption carrier is higher in pathogenic substance clearance rate, ligand molecules are not prone to falling off, and the immunoadsorption carrier can be used for plasma adsorption and can also be directly used for whole blood adsorption; meanwhile, small and medium molecular pathogenic substances such as urea and creatinine can be removed through hemodialysis or hemodialysis filtration. The amino-containing anticoagulant is introduced into the solid-phase carrier, so that the prepared immunoadsorption material has self-anticoagulant property, in the blood purification process, the additional anticoagulant can be reduced or even completely not used, and the risk of bleeding of a patient is greatly reduced.