The invention provides a whole-liver bioartificial liver
system which comprises a
plasma separation and circulation passage, a
liver perfusion circulation passage, a
plasma separation and return circulation passage and a blood
storage tank which are relatively independent, and the blood
storage tank is used for mixing
plasma of a patient and an in-vitro liver
oxygen carrier; the plasma separation and circulation passage comprises a blood input pipeline, a first plasma separation pipeline and a blood return pipeline, and the first plasma separation pipeline is connected with the blood
storage tank; the
liver perfusion circulation path comprises a biochemical purification pipeline provided with a whole
liver perfusion assembly, and the biochemical purification pipeline is connected with the blood storage tank; the plasma separation and return circulation passage comprises a second plasma separation circulation pipeline and a plasma return pipeline, the input end of the second plasma separation circulation pipeline is connected with the output end of the blood storage tank, and the plasma return pipeline is connected between the second plasma separation circulation pipeline and the blood return pipeline. By arranging the blood storage tank, the
perfusion pressure, flow and flow velocity of the in-vitro liver can be better adjusted, the
perfusion efficiency is improved, and the
circulation time is shortened.