Venlafaxine hydrochloride sustained-release capsule and preparation method thereof

[0036]

[0037] Preparation method: Weigh the prescribed amount of venlafaxine hydrochloride and add it to a certain amount of ethanol, stir and dissolve to make a drug solution; then weigh the prescribed amount of hypromellose and add it to a certain amount of water, stir to dissolve, and then Add the prescription amount of talcum powder to make spacer; add polyvinyl acetate-povidone to water to make dispersion liquid, then add triethyl citrate and talc powder, and stir to make it evenly dispersed. Use the sucrose core as the substrate to coat the drug solution, spacer, and coating solution on the surface of the core by using a fluidized bed until the coating solution is completely sprayed to obtain drug-containing sustained-release pellets, and the drug-containing pellets Fill into hard capsules.

[0039]

[0040] The preparation method is the same as in Example 1.

[0042]

[0043] The preparation method is the same as in Example 1.