Low bitter taste levodropropizine oral solution

[0033] Example 1

[0034] A low-bitter levopiperazine oral solution, which contains:

[0035] Main medicine: Cyclodextrin-embedded levopiperazine 2g;

[0036] Accessories: 30g / L citric acid aqueous solution 3~4g;

[0037] Accessories: sucrose 345.g;

[0038] Accessories: orange flavor 0.1g;

[0039] Excipients: methyl paraben 0.25g;

[0040] Excipients: propyl paraben 0.15;

[0041] Accessories: 30% ethanol water 10ml;

[0042] Diluent: purified water to 1000ml

[0043] The pH regulator adjusts the pH value of the levoxipropiazine oral solution to 5.6. .

[0044] The preparation method of the cyclodextrin-embedded levopiperazine is as follows:

[0045] (1) Preparation of Levopropiperazine Dispersion: Weigh 10 parts of Levopropiperazine, 10 parts of β-cyclodextrin, 1 part of gum arabic and 50 parts of water in parts by weight, and stir it evenly with 800W power Ultrasound for 0.5 hours to obtain a dispersion of levopiprazine;

[0046] (2) Homogenization: The levoxipropiperazine dispersion obtai

[0048] Example 2

[0049] A low-bitter levopiperazine oral solution, which contains:

[0050] Main medicine: Cyclodextrin-embedded levoxipropiperazine 8g;

[0051] Accessories: 50g / L lactic acid aqueous solution 4g;

[0052] Accessories: sucrose 360g;

[0053] Accessories: grape flavor 0.5g;

[0054] Excipients: methyl paraben 0.31g;

[0055] Excipients: propyl paraben 0.19g;

[0056] Accessories: 60% ethanol water 5ml;

[0057] Diluent: purified water to 1000ml

[0058] The pH regulator adjusts the pH value of the levoxiprozine oral solution to 6.8.

[0059] The preparation method of the cyclodextrin-embedded levopiperazine is as follows:

[0060] (1) Preparation of Levopropiperazine Dispersion: Weigh 20 parts of Levopropiperazine, 20 parts of β-cyclodextrin, 3 parts of Gum Arabic and 50 parts of water in parts by weight, and stir it evenly with 800W power Ultrasound for 0.5 hours to obtain a dispersion of levopiprazine;

[0061] (2) Homogenization: Place the levoxipropiperazine dispersion obt

[0063] Example 3

[0064] A low-bitter levopiperazine oral solution, which contains:

[0065] Main medicine: Cyclodextrin-encapsulated levoxipropiperazine 6g;

[0066] Excipients: 40g / L tartaric acid 3.5g;

[0067] Accessories: 350g of sucrose;

[0068] Accessories: Apple flavor 0.3g;

[0069] Excipients: methyl paraben 0.22g;

[0070] Excipients: 0.13g of propyl paraben;

[0071] Accessories: 50% ethanol water 8ml;

[0072] Diluent: add purified water to 1000ml;

[0073] The pH regulator adjusts the pH of the levoxipropiperazine oral solution to 5.9.

[0074] The preparation method of the cyclodextrin-embedded levopiperazine is as follows:

[0075] (1) Preparation of Levopropiperazine Dispersion: Weigh 15 parts of Levopropiperazine, 15 parts of β-cyclodextrin, 2 parts of gum arabic and 50 parts of water in parts by weight, and stir it to 800W power. Ultrasound for 0.5 hours to obtain a dispersion of levopiprazine;

[0076] (2) Homogenization: the levoxipropiperazine dispersion obtained in step