Elemene and cabazitaxel double-targeted biomimetic liposome as well as preparation method and application thereof

[0042] Example 1 (elemene content 0.4%, absolute ethanol 1.25%, cabazitaxel 0.04%, oil 0.5%, polyethylene glycol derivative 0.5%, phospholipid 2.5%, cholesterol 0.1%, DSPE-PEG2000-transfer iron Egg 0.05%, tumor cell membrane protein 0.025%)

[0043] An elemene-cabazitaxel double-targeted biomimetic liposome, calculated in 20 mL, comprises the following raw materials: cabazitaxel 8 mg, absolute ethanol 0.25 mL, MCT 100 mg, TPGS 100 mg, soybean lecithin 500 mg, elemene 80 mg, DSPE-PEG2000-transferrin 10mg, cholesterol 20mg, tumor cell membrane protein 5mg, glycerol 520mg, and the rest are water.

[0044] The preparation method of the above-mentioned elemene-cabazitaxel double-targeted biomimetic liposome is:

[0045] (1) Oil phase preparation: take cabazitaxel and dissolve it in absolute ethanol by ultrasonic, add MCT, TPGS, soybean lecithin, elemene, cholesterol, DSPE-PEG2000-transferrin, and dissolve in a water bath at 80°C;

[0046] (2) Preparation of water phase: dissolve gly

[0048] Example 2 (elemene content 0.15%)

[0049] The difference from Example 1 is that the amount of elemene is 30 mg.

[0050] Example 3 (elemene content 0.75%)

[0051] The difference from Example 1 is that the amount of elemene is 150 mg.