Multi-model predictive control method for pichia pastoris fermentation process

A technology of Pichia pastoris and fermentation process, which is applied in character and pattern recognition, instruments, electrical digital data processing, etc. It can solve the problem of inability to weaken the influence of model mismatch, affect the steady state and dynamic performance of the fermentation process, and the control effect is not ideal, etc. problem, to achieve good output tracking, improve transient response, and achieve the effect of output tracking

Active Publication Date: 2022-04-29
JIANGSU UNIV
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Problems solved by technology

Although MPC has strong robustness and is suitable for large time-delay systems, the control effect is not ideal when it is applied to the fermentation process of Pichia pastoris with strong nonlinearity and parameters ch

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  • Multi-model predictive control method for pichia pastoris fermentation process
  • Multi-model predictive control method for pichia pastoris fermentation process
  • Multi-model predictive control method for pichia pastoris fermentation process

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Embodiment Construction

[0071] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0072] see figure 1 ~7. The embodiment of the present invention provides a multi-model predictive control method for the fermentation process of Pichia pastoris, the method comprising:

[0073] 1.1 Multi-model modeling based on FCM-IPSO-LSSVM

[0074] The basic idea of ​​multi-model predictive control is to divide the nonlinear space of the controlled object into several subspaces. Then, local models are established in each subspace, and corresponding predictiv

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Abstract

The invention discloses a multi-model predictive control method for a pichia pastoris fermentation process. The multi-model predictive control method comprises the following steps: dividing prior data into m training sample sets (sample clusters) by utilizing a fuzzy C-means clustering algorithm (FCM); for each sample cluster, a corresponding prediction model is obtained by adopting a least square support vector machine (LSSVM) and an improved particle swarm optimization (IPSO) method, then corresponding prediction controllers are respectively designed for m local prediction models, and finally, the deviation between the output of an object and the output of each sub-prediction model is calculated at each sampling moment, so that a prediction result is obtained. A multi-model fusion predictive controller is constructed based on a multi-model relative error weighting algorithm, and the pichia pastoris fermentation process is controlled by using the control method. According to the method, the adaptive capacity of the model is improved, so that the actual state of the nonlinear system is described more accurately.

Description

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Claims

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Application Information

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Owner JIANGSU UNIV
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