Dry Powder Drug Containment System Packages with Tabs, Inhalers and Associated Methods

Inactive Publication Date: 2007-09-27
ORIEL THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0023] Embodiments of the present invention provide dry powder packages, inhalers, and/or methods for operating same that can be used with dry powder inhalers. In some embodiments, the drug compartments can have active piezoelectric components. Alternatively or additionally, the inhaler can have an active piezoelectric component forming a part of the flow path away from the drug compartment to facilitate fluidic drug dispersion.

Problems solved by technology

Unfortunately, this passive operation can lead to poor dosing uniformity because inspiratory capabilities can vary from patient to patient (and sometimes even use-to-use by the same patient, particularly if the patient is undergoing an asthmatic attack or respiratory-type ailment which tends to close the airway).
If the patient is unable to provide sufficient respiratory effort, the extent of drug penetration, especially to the lower portion of the airway, may be impeded.
This may result in premature deposit of the powder in the patient's mouth or throat.
A number of obstacles can undesirably impact the performance of the DPI.
For example, the small size of the inhalable particles in the dry powder drug mixture can subject them to forces of agglomeration and/or cohesion (i.e., certain types of dry powders are susceptible to agglomeration, which is typically caused by particles of the drug adhering together), which can result in poor flow and non-uniform dispersion.
However, separation of the drug from the excipient, as well as the presence of agglomeration, can require additional inspiratory effort, which, again, can impact the stable dispersion of the powder within the air stream of the patient.
Unstable dispersions may inhibit the drug from reaching its preferred deposit/destination site and can prematurely deposit undue amounts of the drug elsewhere.
Further, many dry powder inhalers can retain a significant amount of the drug within the device, which can be especially problematic over time.
In addition, the hygroscopic nature of many of these dry powder drugs may also require that the device be cleansed (and dried) at periodic intervals.

Method used

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  • Dry Powder Drug Containment System Packages with Tabs, Inhalers and Associated Methods
  • Dry Powder Drug Containment System Packages with Tabs, Inhalers and Associated Methods
  • Dry Powder Drug Containment System Packages with Tabs, Inhalers and Associated Methods

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[0046] The present invention will now be described more fully hereinafter with reference to the accompanying figures, in which embodiments of the invention are shown. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Like numbers refer to like elements throughout. In the figures, certain layers, components or features may be exaggerated for clarity, and broken lines illustrate optional features or operations unless specified otherwise. In addition, the sequence of operations (or steps) is not limited to the order presented in the figures and / or claims unless specifically indicated otherwise. In the drawings, the thickness of lines, layers, features, components and / or regions may be exaggerated for clarity and broken lines illustrate optional features or operations, unless specified otherwise.

[0047] It will be understood that when a feature, such as a layer, region or substrate, is referred t

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Abstract

Dry powder drug containment packages with tab members and meted dose sealed drug compartments can be used in an inhaler having a flow chamber with a hook member that opens the drug compartments and/or a portion that flexes to vibrate the dry powder to facilitate fluidic active dispersion for inhalation.

Description

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Claims

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Application Information

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Owner ORIEL THERAPEUTICS INC
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