The present invention relates to the field of medicines and health-care products, and particularly relates to a cancer-preventing and -resisting and aging-resisting medicine/health-care product and a preparation method and a preparation device thereof. Xanthohumol and mannan are extracted; selenium-enriched malt seedlings, edible fungi, apocynum venetum tea, phellinus igniarius are ultrafine crushed or lixiviated and concentrated; the xanthohumol and mannan extracted concentrate and the above-mentioned powdered product or the lixiviated concentrate are used as raw materials; and the solid or liquid medicine/health-care product with cancer-preventing and -resisting, aging-resisting and atrophy-resisting effects are prepared according to the scientific formula. Advantages: first, active ingredients of the extract are high in purity, giving full play to synergistic actions between the xanthohumol and mannan and the selenium-enriched malt seedlings, edible fungi, apocynum venetum tea and phellinus igniarius, so that the medicine/health-care product has obvious cancer-preventing and -resisting, aging-resisting and muscular atrophy -resisting curative effects; second, the medicine/health-care product is rich in nutrition, and can lower cholesterol, protect the liver, prevent cardiovascular diseases and improve self-immunity; and third, the preparation method and the preparation device are simple and less in investments.